T cells exercise a multitude of functions such as cytotoxicity, secretion of immunomodulating
cytokines or regulation of tolerance, collectively resulting in an effective control of immune …

Over the last few years, there has been a rapid expansion in the application of information
technology to biological data. Particularly the field of immunology has seen great strides in …

BACKGROUND The biology of Plasmodium vivax is markedly different from that of P.
falciparum; how this shapes the immune response to infection remains unclear. To address …

Naive CD4+ T cells must differentiate in order to orchestrate immunity to Plasmodium, yet
understanding of their emerging phenotypes, clonality, spatial distributions, and cellular …

Infections are highly orchestrated and dynamic processes, which involve both pathogen and
host. Transcriptional profiling at the single-cell level enables the analysis of cell diversity …

With the improvement of treatment options, multiple myeloma related life expectancy has
been prolonged, but the disease remains largely incurable. Immunotherapy is a growing …

Immunity to severe malaria is acquired quickly, operates independently of pathogen load
and represents a highly effective form of disease tolerance. The mechanism that underpins …

The changes occurring in the T cell repertoire during clinical malaria infection in children
remain unknown. In this study, we undertook the first detailed comparative study of the T cell …

BACKGROUND: Immunogenomics approaches to the characterization of renal cell
carcinoma (RCC) have helped to better our understanding of the features of RCC immune …

Plasmodium vivax offers unique challenges for malaria control and may prove a more
difficult species to eradicate than Plasmodium falciparum. Yet compared to P. falciparum we …