Dissecting the mechanisms of cell division
JY Ong, JZ Torres - Journal of Biological Chemistry, 2019 - ASBMB
Cell division is a highly regulated and carefully orchestrated process. Understanding the
mechanisms that promote proper cell division is an important step toward unraveling …
mechanisms that promote proper cell division is an important step toward unraveling …
Eukaryotic cell size regulation and its implications for cellular function and dysfunction
Y Chadha, A Khurana… - Physiological …, 2024 - journals.physiology.org
Depending on cell type, environmental inputs, and disease, the cells in the human body can
have widely different sizes. In recent years, it became clear that cell size is a major regulator …
have widely different sizes. In recent years, it became clear that cell size is a major regulator …
The fission yeast cell size control system integrates pathways measuring cell surface area, volume, and time
KE Miller, C Vargas-Garcia, A Singh, JB Moseley - Current Biology, 2023 - cell.com
Eukaryotic cells tightly control their size, but the relevant aspect of size is unknown in most
cases. Fission yeast divide at a threshold cell surface area (SA) due, in part, to the protein …
cases. Fission yeast divide at a threshold cell surface area (SA) due, in part, to the protein …
The number of cytokinesis nodes in mitotic fission yeast scales with cell size
WA Sayyad, TD Pollard - Elife, 2022 - elifesciences.org
Cytokinesis nodes are assemblies of stoichiometric ratios of proteins associated with the
plasma membrane, which serve as precursors for the contractile ring during cytokinesis by …
plasma membrane, which serve as precursors for the contractile ring during cytokinesis by …
Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast
E Scotchman, K Kume, FJ Navarro… - Journal of cell …, 2021 - journals.biologists.com
Fission yeast cells divide at a similar cell length with little variation about the mean. This is
thought to be the result of a control mechanism that senses size and corrects for any …
thought to be the result of a control mechanism that senses size and corrects for any …
Pattern formation and complexity in single cells
WF Marshall - Current Biology, 2020 - cell.com
In the context of animal or plant development, we tend to think of cells as small, simple,
building blocks, such that complex patterns or shapes can only be constructed from large …
building blocks, such that complex patterns or shapes can only be constructed from large …
A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1
To enter into mitosis, cells must shut off the cell cycle inhibitor Wee1. SAD family protein
kinases regulate Wee1 signaling in yeast and humans. In Schizosaccharomyces pombe …
kinases regulate Wee1 signaling in yeast and humans. In Schizosaccharomyces pombe …
Intracellular morphogens: specifying patterns at the subcellular scale
L Hubatsch, NW Goehring - Current Topics in Developmental Biology, 2020 - Elsevier
The notion that graded distributions of signals underlie the spatial organization of biological
systems has long been a central pillar in the fields of cell and developmental biology. During …
systems has long been a central pillar in the fields of cell and developmental biology. During …
Machine-learning-enabled design and manipulation of a microfluidic concentration gradient generator
Microfluidics concentration gradient generators have been widely applied in chemical and
biological fields. However, the current gradient generators still have some limitations. In this …
biological fields. However, the current gradient generators still have some limitations. In this …
Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division
HE Opalko, KE Miller, HS Kim, CA Vargas-Garcia… - Journal of Cell …, 2021 - rupress.org
Fission yeast cells prevent mitotic entry until a threshold cell surface area is reached. The
protein kinase Cdr2 contributes to this size control system by forming multiprotein nodes that …
protein kinase Cdr2 contributes to this size control system by forming multiprotein nodes that …