Update on the effects of microgravity on the musculoskeletal system

OJ Juhl IV, EG Buettmann, MA Friedman… - npj …, 2021 - nature.com
With the reignited push for manned spaceflight and the development of companies focused
on commercializing spaceflight, increased human ventures into space are inevitable …

The effects of microgravity on bone structure and function

J Man, T Graham, G Squires-Donelly, AL Laslett - npj Microgravity, 2022 - nature.com
Humans are spending an increasing amount of time in space, where exposure to conditions
of microgravity causes 1–2% bone loss per month in astronauts. Through data collected …

Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D3

F Mammoli, S Castiglioni, S Parenti… - International journal of …, 2019 - mdpi.com
Magnesium (Mg) is crucial for bone health. Low concentrations of Mg inhibit the activity of
osteoblasts while promoting that of osteoclasts, with the final result of inducing osteopenia …

Microgravity-related changes in bone density and treatment options: A systematic review

R Baran, M Wehland, H Schulz, M Heer… - International Journal of …, 2022 - mdpi.com
Space travelers are exposed to microgravity (µ g), which induces enhanced bone loss
compared to the age-related bone loss on Earth. Microgravity promotes an increased bone …

The impact of oxidative stress on the bone system in response to the space special environment

Y Tian, X Ma, C Yang, P Su, C Yin, AR Qian - International Journal of …, 2017 - mdpi.com
The space special environment mainly includes microgravity, radiation, vacuum and
extreme temperature, which seriously threatens an astronaut's health. Bone loss is one of …

Tissue engineering under microgravity conditions–use of stem cells and specialized cells

D Grimm, M Egli, M Krüger, S Riwaldt… - Stem Cells and …, 2018 - liebertpub.com
Experimental cell research studying three-dimensional (3D) tissues in space and on Earth
using new techniques to simulate microgravity is currently a hot topic in Gravitational Biology …

Toxicity induction of nanopolystyrene under microgravity stress condition in Caenorhabditis elegans

Y Zhao, D Li, Q Rui, D Wang - Science of the Total Environment, 2020 - Elsevier
Caenorhabditis elegans is a useful animal model for assessing adverse effects of
environmental toxicants or stresses. C. elegans was used as an assay system to investigate …

Mitochondrial Unfolded Protein Response to Microgravity Stress in Nematode Caenorhabditis elegans

P Liu, D Li, W Li, D Wang - Scientific Reports, 2019 - nature.com
Caenorhabditis elegans is useful for assessing biological effects of spaceflight and
simulated microgravity. The molecular response of organisms to simulated microgravity is …

Impact of simulated microgravity on cytoskeleton and viscoelastic properties of endothelial cell

M Janmaleki, M Pachenari, SM Seyedpour… - Scientific reports, 2016 - nature.com
This study focused on the effects of simulated microgravity (s-μg) on mechanical properties,
major cytoskeleton biopolymers, and morphology of endothelial cells (ECs). The structural …

Silver nanoparticles in orthopedic applications: New insights on their effects on osteogenic cells

S Castiglioni, A Cazzaniga, L Locatelli, JAM Maier - Nanomaterials, 2017 - mdpi.com
Infections of orthopedic implants are associated with high morbidity. The emergence of
antibiotic resistant strains and the tendency of microbes to form biofilms on orthopedic …