Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …

Abstract Cytochrome P450 (CYP) family 1, 2, and 3 enzymes play an essential role in the
metabolic clearance and detoxification of a myriad of structurally and chemically diverse …

Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We
have developed a family of steroid-based facial amphiphiles (FAs) that are structurally …

Cytochrome P450 (CYP) epoxygenases are a special subset of heme-containing CYP
enzymes capable of performing the epoxidation of polyunsaturated fatty acids (PUFA) and …

X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or
mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These …

Cytochrome P450 enzymes are renowned for their ability to insert oxygen into an enormous
variety of compounds with a high degree of chemo-and regio-selectivity under mild …

The superfamily of cytochrome P450s forms a large class of heme monooxygenases with
more than 13,000 enzymes represented in organisms from all biological kingdoms. Despite …

The non-covalent interactions between small drug molecules and disease-related proteins
(ligand-target interactions) mediate various pharmacological processes in the treatment of …

Promiscuous and allosteric drug interactions with cytochrome P450 3A4 (CYP3A4) are
ubiquitous but incompletely understood at the molecular level. A classic allosteric CYP3A4 …