Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy
R Du, C Huang, K Liu, X Li, Z Dong - Molecular cancer, 2021 - Springer
Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …
[HTML][HTML] Aurora kinases: novel therapy targets in cancers
A Tang, K Gao, L Chu, R Zhang, J Yang, J Zheng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA),
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …
Aurora A kinase (AURKA) in normal and pathological cell division
Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …
Aurora‐A kinase: a potent oncogene and target for cancer therapy
M Yan, C Wang, B He, M Yang, M Tong… - Medicinal research …, 2016 - Wiley Online Library
The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …
The RASSF proteins in cancer; from epigenetic silencing to functional characterization
The Ras-Association Domain Family (RASSF) comprises ten members, termed RASSF1 to
RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and …
RASSF10. RASSF1 to RASSF6 harbor a C-terminal Ras-association (RA) domain and …
[HTML][HTML] The Ras-association domain family (RASSF) members and their role in human tumourigenesis
L van der Weyden, DJ Adams - … et Biophysica Acta (BBA)-Reviews on …, 2007 - Elsevier
Ras proteins play a direct causal role in human cancer with activating mutations in Ras
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …
occurring in∼ 30% of tumours. Ras effectors also contribute to cancer, as mutations occur in …
The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma
K Ma, B Cao, M Guo - Clinical epigenetics, 2016 - Springer
Esophageal cancer is one of the most common malignancies in the world. Squamous cell
carcinoma accounts for approximately 90% of esophageal cancer cases. Genetic and …
carcinoma accounts for approximately 90% of esophageal cancer cases. Genetic and …
Aurora kinase inhibitors as potential anticancer agents: Recent advances
Aurora kinases are a family of serine/threonine kinases that play a crucial role in cell
proliferation through the regulation of mitotic spindles. These kinases are the regulatory …
proliferation through the regulation of mitotic spindles. These kinases are the regulatory …
[HTML][HTML] RASSF tumor suppressor gene family: biological functions and regulation
N Volodko, M Gordon, M Salla, HA Ghazaleh, S Baksh - FEBS letters, 2014 - Elsevier
Genetic changes through allelic loss and nucleic acid or protein modifications are the main
contributors to loss of function of tumor suppressor proteins. In particular, epigenetic …
contributors to loss of function of tumor suppressor proteins. In particular, epigenetic …
RASSF1A, puppeteer of cellular homeostasis, fights tumorigenesis, and metastasis—An updated review
The Ras association domain family protein1 isoform A (RASSF1A) is a well-known tumor-
suppressor protein frequently inactivated in various human cancers. Consistent with its …
suppressor protein frequently inactivated in various human cancers. Consistent with its …