Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master
regulator of cell growth and metabolism, forms two structurally and functionally distinct …

Ferroptosis is an iron‐dependent, oxidative form of non‐apoptotic cell death. This form of
cell death does not share morphological, biochemical, or genetic similarities with classic …

MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by
therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic …

Cancer cells exhibit an abnormal amino acid metabolism and a dependence on specific
amino acids, which might provide potential targets for treating cancer patients. In this study …

Cellular growth and proliferation depend upon the acquisition and synthesis of specific
metabolites. These metabolites fuel the bioenergy, biosynthesis, and redox potential …

The mechanistic/mammalian target of rapamycin (mTOR), a protein discovered in 1991,
integrates a complex pathway with a key role in maintaining cellular homeostasis. By …

Background Interferon-gamma (IFNγ) exerts potent growth inhibitory effects on a wide range
of cancer cells through unknown signaling pathways. We pursued complementary screening …

Restricting availability of essential amino acids (EAAs) limits aminoacylation of tRNAs by
their cognate EAAs and activates the nutrient-sensing kinase, general control …

Metabolic stress occurs frequently in tumors and in normal tissues undergoing transient
ischemia. Nutrient deprivation triggers, among many potential cell death-inducing pathways …

Excessive consumption of fructose in the Western diet contributes to cancer development.
However, it is still unclear how cancer cells coordinate glucose and fructose metabolism …