Ferroptosis: bug or feature?
SJ Dixon - Immunological reviews, 2017 - Wiley Online Library
Ferroptosis is an iron‐dependent, oxidative form of non‐apoptotic cell death. This form of
cell death does not share morphological, biochemical, or genetic similarities with classic …
cell death does not share morphological, biochemical, or genetic similarities with classic …
[HTML][HTML] Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma
WD Gwynne, Y Suk, S Custers, N Mikolajewicz… - Cancer Cell, 2022 - cell.com
MYC-driven medulloblastoma (MB) is an aggressive pediatric brain tumor characterized by
therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic …
therapy resistance and disease recurrence. Here, we integrated data from unbiased genetic …
[HTML][HTML] CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the …
Cancer cells exhibit an abnormal amino acid metabolism and a dependence on specific
amino acids, which might provide potential targets for treating cancer patients. In this study …
amino acids, which might provide potential targets for treating cancer patients. In this study …
Cancer metabolism and the evasion of apoptotic cell death
A Sharma, LH Boise, M Shanmugam - Cancers, 2019 - mdpi.com
Cellular growth and proliferation depend upon the acquisition and synthesis of specific
metabolites. These metabolites fuel the bioenergy, biosynthesis, and redox potential …
metabolites. These metabolites fuel the bioenergy, biosynthesis, and redox potential …
Expression of mTOR in normal and pathological conditions
A Marques-Ramos, R Cervantes - Molecular cancer, 2023 - Springer
The mechanistic/mammalian target of rapamycin (mTOR), a protein discovered in 1991,
integrates a complex pathway with a key role in maintaining cellular homeostasis. By …
integrates a complex pathway with a key role in maintaining cellular homeostasis. By …
ERK mediates interferon gamma-induced melanoma cell death
A Champhekar, R Heymans, J Saco, G Turon Font… - Molecular Cancer, 2023 - Springer
Background Interferon-gamma (IFNγ) exerts potent growth inhibitory effects on a wide range
of cancer cells through unknown signaling pathways. We pursued complementary screening …
of cancer cells through unknown signaling pathways. We pursued complementary screening …
Role of GCN2-independent signaling through a noncanonical PERK/NRF2 pathway in the physiological responses to dietary methionine restriction
Restricting availability of essential amino acids (EAAs) limits aminoacylation of tRNAs by
their cognate EAAs and activates the nutrient-sensing kinase, general control …
their cognate EAAs and activates the nutrient-sensing kinase, general control …
Glucose deprivation induces ATF4-mediated apoptosis through TRAIL death receptors
R Iurlaro, F Püschel… - … and cellular biology, 2017 - Taylor & Francis
Metabolic stress occurs frequently in tumors and in normal tissues undergoing transient
ischemia. Nutrient deprivation triggers, among many potential cell death-inducing pathways …
ischemia. Nutrient deprivation triggers, among many potential cell death-inducing pathways …
ATF4-dependent fructolysis fuels growth of glioblastoma multiforme
C Chen, Z Zhang, C Liu, B Wang, P Liu, S Fang… - Nature …, 2022 - nature.com
Excessive consumption of fructose in the Western diet contributes to cancer development.
However, it is still unclear how cancer cells coordinate glucose and fructose metabolism …
However, it is still unclear how cancer cells coordinate glucose and fructose metabolism …