Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

The thermodynamically unstable nature of amorphous drugs has led to a persistent stability
issue of amorphous solid dispersions (ASDs). Lately, microwave-induced in situ …

In situ amorphization is a concept that allows to amorphize a given drug in its final dosage
form right before administration. Hence, this approach can potentially be used to circumvent …

In this study, the influence of drug load on the microwave-induced amorphization of
celecoxib (CCX) in polyvinylpyrrolidone (PVP) tablets was investigated using quantitative …

The aim of this study was to improve the oral bioavailability of a practically insoluble drug,
efonidipine hydrochloride (EFH), by agglomeration in acid solution/gastric fluid. The EFH …

Background Efonidipine hydrochloride (EFO) is a poorly water-soluble drug and, hence, has
poor bioavailability. Solid dispersions (SDs) of EFO using Eudragit EPO were prepared …

Intranasal administration has attracted increasing attention as a drug delivery approach
based on nose-to-brain drug delivery from the nasal cavity to brain tissue directly, bypassing …

This work explores the use of UV imaging in solid dispersion systems. Solid dispersions are
one of the common strategies used in improving the dissolution of poorly soluble drugs …

The aim of this present study was to investigate the ability of different dissolution methods to
predict the in vivo performance of efonidipine hydrochloride (EFH). The solid dispersions of …