The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine
Abstract Mesenchymal Stem Cells (MSCs) have been shown to be a promising candidate for
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …
Mesenchymal stromal cell-based bone regeneration therapies: from cell transplantation and tissue engineering to therapeutic secretomes and extracellular vesicles
D Marolt Presen, A Traweger, M Gimona… - … in bioengineering and …, 2019 - frontiersin.org
Effective regeneration of bone defects often presents significant challenges, particularly in
patients with decreased tissue regeneration capacity due to extensive trauma, disease …
patients with decreased tissue regeneration capacity due to extensive trauma, disease …
Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene‐related peptide
The neuronal engagement of the peripheral nerve system plays a crucial role in regulating
fracture healing, but how to modulate the neuronal activity to enhance fracture healing …
fracture healing, but how to modulate the neuronal activity to enhance fracture healing …
[HTML][HTML] Mesenchymal stem cell exosomes in bone regenerative strategies—a systematic review of preclinical studies
The ability of bone for regeneration has long been recognized. However, once beyond a
critical size, spontaneous regeneration of bone is limited. Several studies have focused on …
critical size, spontaneous regeneration of bone is limited. Several studies have focused on …
Bioprocessing of mesenchymal stem cells and their derivatives: Toward cell‐free therapeutics
Mesenchymal stem cells (MSCs) have attracted tremendous research interest due to their
ability to repair tissues and reduce inflammation when implanted into a damaged or …
ability to repair tissues and reduce inflammation when implanted into a damaged or …
Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis
Y Jia, Y Zhu, S Qiu, J Xu, Y Chai - Stem cell research & therapy, 2019 - Springer
Background Distraction osteogenesis (DO) is an effective but lengthy procedure to fully
induce bone regeneration in large bone defects. Accumulating evidence supports the role of …
induce bone regeneration in large bone defects. Accumulating evidence supports the role of …
Immune modulation by transplanted calcium phosphate biomaterials and human mesenchymal stromal cells in bone regeneration
P Humbert, MÁ Brennan, N Davison, P Rosset… - Frontiers in …, 2019 - frontiersin.org
A wide variety of biomaterials have been developed as both stabilizing structures for the
injured bone and inducers of bone neoformation. They differ in chemical composition …
injured bone and inducers of bone neoformation. They differ in chemical composition …
Gold nanorods modified by endogenous protein with light-irradiation enhance bone repair via multiple osteogenic signal pathways
H Shan, X Zhou, B Tian, C Zhou, X Gao, C Bai, B Shan… - Biomaterials, 2022 - Elsevier
Fracture is one of the most common clinical diseases that reduce the quality of patients' lives
significantly. In this study, we prepared gold nanorods modified by endogenous proteins …
significantly. In this study, we prepared gold nanorods modified by endogenous proteins …
Impaired bone regenerative effect of exosomes derived from bone marrow mesenchymal stem cells in type 1 diabetes
Y Zhu, Y Jia, Y Wang, J Xu, Y Chai - Stem Cells Translational …, 2019 - academic.oup.com
Stem cell-derived exosomes have exhibited promise for applications in tissue regeneration.
However, one major problem for stem cell-derived exosome therapies is identifying …
However, one major problem for stem cell-derived exosome therapies is identifying …
Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications
Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors
in the field of medical tissue engineering and cell free biotherapy due to their ease of …
in the field of medical tissue engineering and cell free biotherapy due to their ease of …