The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine

P Kumar, S Kandoi, R Misra, S Vijayalakshmi… - Cytokine & growth factor …, 2019 - Elsevier
Abstract Mesenchymal Stem Cells (MSCs) have been shown to be a promising candidate for
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …

Mesenchymal stromal cell-based bone regeneration therapies: from cell transplantation and tissue engineering to therapeutic secretomes and extracellular vesicles

D Marolt Presen, A Traweger, M Gimona… - … in bioengineering and …, 2019 - frontiersin.org
Effective regeneration of bone defects often presents significant challenges, particularly in
patients with decreased tissue regeneration capacity due to extensive trauma, disease …

Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene‐related peptide

J Mi, JK Xu, Z Yao, H Yao, Y Li, X He, BY Dai… - Advanced …, 2022 - Wiley Online Library
The neuronal engagement of the peripheral nerve system plays a crucial role in regulating
fracture healing, but how to modulate the neuronal activity to enhance fracture healing …

[HTML][HTML] Mesenchymal stem cell exosomes in bone regenerative strategies—a systematic review of preclinical studies

SHS Tan, JRY Wong, SJY Sim, CKE Tjio, KL Wong… - Materials Today Bio, 2020 - Elsevier
The ability of bone for regeneration has long been recognized. However, once beyond a
critical size, spontaneous regeneration of bone is limited. Several studies have focused on …

Bioprocessing of mesenchymal stem cells and their derivatives: Toward cell‐free therapeutics

J Phelps, A Sanati-Nezhad, M Ungrin… - Stem Cells …, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) have attracted tremendous research interest due to their
ability to repair tissues and reduce inflammation when implanted into a damaged or …

Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis

Y Jia, Y Zhu, S Qiu, J Xu, Y Chai - Stem cell research & therapy, 2019 - Springer
Background Distraction osteogenesis (DO) is an effective but lengthy procedure to fully
induce bone regeneration in large bone defects. Accumulating evidence supports the role of …

Immune modulation by transplanted calcium phosphate biomaterials and human mesenchymal stromal cells in bone regeneration

P Humbert, MÁ Brennan, N Davison, P Rosset… - Frontiers in …, 2019 - frontiersin.org
A wide variety of biomaterials have been developed as both stabilizing structures for the
injured bone and inducers of bone neoformation. They differ in chemical composition …

Gold nanorods modified by endogenous protein with light-irradiation enhance bone repair via multiple osteogenic signal pathways

H Shan, X Zhou, B Tian, C Zhou, X Gao, C Bai, B Shan… - Biomaterials, 2022 - Elsevier
Fracture is one of the most common clinical diseases that reduce the quality of patients' lives
significantly. In this study, we prepared gold nanorods modified by endogenous proteins …

Impaired bone regenerative effect of exosomes derived from bone marrow mesenchymal stem cells in type 1 diabetes

Y Zhu, Y Jia, Y Wang, J Xu, Y Chai - Stem Cells Translational …, 2019 - academic.oup.com
Stem cell-derived exosomes have exhibited promise for applications in tissue regeneration.
However, one major problem for stem cell-derived exosome therapies is identifying …

Extracellular vesicles in bone and periodontal regeneration: current and potential therapeutic applications

L Gholami, VT Nooshabadi, S Shahabi, M Jazayeri… - Cell & Bioscience, 2021 - Springer
Oral mesenchymal stem cells (MSCs) and their secretomes are considered important factors
in the field of medical tissue engineering and cell free biotherapy due to their ease of …