Cancer is a leading cause of death worldwide and cancer incidence and mortality are
rapidly growing. These massive amounts of cancer patients require rapid diagnosis and …

When released into biological fluids like blood or saliva, brain extracellular vesicles (EVs)
might provide a window into otherwise inaccessible tissue, contributing useful biomarkers of …

Evidence suggests that fasting exerts extensive antitumor effects in various cancers,
including colorectal cancer (CRC). However, the mechanism behind this response is …

Importance Exenatide, a glucagon-like peptide 1 agonist used in type 2 diabetes, was
recently found to have beneficial effects on motor function in a randomized, placebo …

Fluid biomarkers for cognitive impairment have the advantage of being relatively
noninvasive and capable of monitoring neuronal and other brain cell health in real time …

Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging
contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of …

Importance Blood biomarkers able to diagnose Alzheimer disease (AD) at the preclinical
stage would enable trial enrollment when the disease is potentially reversible. Plasma …

Background: Strong preclinical evidence suggests that exenatide, a glucagon-like peptide-1
(GLP-1) receptor agonist used for treating type 2 diabetes, is neuroprotective and disease …

Highlights•Traditional calorie restriction robustly improves markers of aging in
humans.•Novel dietary strategies may be substitutes for calorie restriction.•Intermittent …

Background: Insulin resistance is implicated in Alzheimer's disease (AD), whereas
intranasal insulin is an experimental treatment in clinical trials. We previously proposed …