Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
RZ Goldstein, ND Volkow - Nature reviews neuroscience, 2011 - nature.com
The loss of control over drug intake that occurs in addiction was initially believed to result
from disruption of subcortical reward circuits. However, imaging studies in addictive …
from disruption of subcortical reward circuits. However, imaging studies in addictive …
The neural mechanisms of inter-temporal decision-making: understanding variability
Humans and animals prefer immediate over delayed rewards (delay discounting). This
preference for smaller-but-sooner over larger-but-later rewards shows substantial …
preference for smaller-but-sooner over larger-but-later rewards shows substantial …
Disruption of reward processing in addiction: an image-based meta-analysis of functional magnetic resonance imaging studies
Importance Disrupted reward processing, mainly driven by striatal dysfunction, is a key
characteristic of addictive behaviors. However, functional magnetic resonance imaging …
characteristic of addictive behaviors. However, functional magnetic resonance imaging …
Disorders of compulsivity: a common bias towards learning habits
Why do we repeat choices that we know are bad for us? Decision making is characterized
by the parallel engagement of two distinct systems, goal-directed and habitual, thought to …
by the parallel engagement of two distinct systems, goal-directed and habitual, thought to …
A neurocognitive approach to understanding the neurobiology of addiction
Recent concepts of addiction to drugs (eg cocaine) and non-drugs (eg gambling) have
proposed that these behaviors are the product of an imbalance between three separate, but …
proposed that these behaviors are the product of an imbalance between three separate, but …
Gambling disorder and other behavioral addictions: recognition and treatment
YHC Yau, MN Potenza - Harvard review of psychiatry, 2015 - journals.lww.com
Addiction professionals and the public are recognizing that certain nonsubstance behaviors—
such as gambling, Internet use, video-game playing, sex, eating, and shopping—bear …
such as gambling, Internet use, video-game playing, sex, eating, and shopping—bear …
The neurocircuitry of impaired insight in drug addiction
More than 80% of addicted individuals fail to seek treatment, which might reflect impairments
in recognition of severity of disorder. Considered by some as intentional deception, such …
in recognition of severity of disorder. Considered by some as intentional deception, such …
[HTML][HTML] Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain
K Rømer Thomsen, PC Whybrow… - Frontiers in behavioral …, 2015 - frontiersin.org
Anhedonia, the lack of pleasure, has been shown to be a critical feature of a range of
psychiatric disorders. Yet, it is currently measured primarily through subjective self-reports …
psychiatric disorders. Yet, it is currently measured primarily through subjective self-reports …
Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity
RF Leeman, MN Potenza - Psychopharmacology, 2012 - Springer
Rationale Pathological gambling (PG) has recently been considered as a “behavioral” or
nonsubstance addiction. A comparison of the characteristics of PG and substance use …
nonsubstance addiction. A comparison of the characteristics of PG and substance use …
Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway
ND Volkow, GJ Wang, JH Newcorn, SH Kollins… - Molecular …, 2011 - nature.com
Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of
inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in …
inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in …