Exploring Natural Compounds as Potential CDK4 Inhibitors for Therapeutic Intervention in Neurodegenerative Diseases through Computational Analysis

N Rani, P Kumar - Molecular Biotechnology, 2024 - Springer
CDK4 is a member of the serine-threonine kinase family, which has been found to be
overexpressed in a plethora of studies related to neurodegenerative diseases. CDK4 is one …

Repurposing Antiviral Drugs as Potential Anti‐EGFR Agents in NSCLC: A Structure‐Based Screening and Molecular Dynamics Analysis

FN Adegboyega, LO Anifowose… - Chemistry & …, 2024 - Wiley Online Library
One of the problems resulting from recurrent hyperactivated or mutant epidermal growth
factor receptors (EGFR) in non‐small cell lung cancer (NSCLC) is therapeutic resistance …

Atomistic simulations suggest dietary flavonoids from Beta vulgaris (beet) as promising inhibitors of human angiotensin-converting enzyme and 2-alpha-adrenergic …

JA Adetunji, OM Ogunyemi, GA Gyebi… - Bioinformatics …, 2023 - academic.oup.com
Motivation Beta vulgaris (beet) is extensively reported for its antihypertensive activity.
However, the mechanismunderpinning its antihypertensive activity is not well understood. In …

Disruption of Oncogenic MCL-1-BAX/BAK Interaction Using Integrase Inhibitors: Insights from a Molecular Docking and Dynamic Exploration

LO Anifowose, FN Adegboyega, OM Ogunyemi… - 2024 - researchsquare.com
Dysregulation of programmed cell death is a hallmark characteristic of cancer cells, making
the apoptotic signaling pathway of important clinical relevance in cancer therapy. In …

In Silico Studies of Chemical Compounds from Punica Granatum› s Peel as Angiotensin-I Converting Enzyme Inhibitor

SP Pishva, A Davood, M Iman - Personalized Medicine Journal, 2023 - pmjournal.ir
Present research on herbal food-derived phenolic compounds as angiotensin-I-converting
enzyme (ACE) inhibitors has been well-documented. Punica granatum L.(pomegranate) is …