[HTML][HTML] New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …
incremental scientific work and all positive socio-political engagements, are steps taken in …
Comprehensive coverage on anti-mycobacterial endeavour reported during 2022
TM Dhameliya, DD Vekariya, HY Patel… - European Journal of …, 2023 - Elsevier
TB being one of the deadliest diseases and second most common infectious cause of
deaths, poses the severe threat to global health. The extended duration of therapy owing to …
deaths, poses the severe threat to global health. The extended duration of therapy owing to …
Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical …
JD Paz, ND de Moura Sperotto, AS Ramos… - European Journal of …, 2023 - Elsevier
Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study
the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis …
the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis …
Oxidative Phosphorylation—an Update on a New, Essential Target Space for Drug Discovery in Mycobacterium tuberculosis
New drugs with new mechanisms of action are urgently required to tackle the global
tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor …
tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor …
Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease
CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …
their potential against several of the world's most important neglected tropical diseases …
Cytochrome bd oxidase: An emerging anti-tubercular drug target
Cytochrome bd (Cyt-bd) oxidase, one of the two terminal oxidases in the Mycobacterium
tuberculosis (Mtb) oxidative phosphorylation pathway, plays an indispensable role in …
tuberculosis (Mtb) oxidative phosphorylation pathway, plays an indispensable role in …
Handling the hurdles on the way to anti-tuberculosis drug development
PF Dalberto, EV De Souza, BL Abbadi… - Frontiers in …, 2020 - frontiersin.org
The global epidemic of tuberculosis (TB) imposes a sustained epidemiologic vigilance and
investments in research by governments. Mycobacterium tuberculosis, the main causative …
investments in research by governments. Mycobacterium tuberculosis, the main causative …
Design, synthesis, and evaluation of new 2-(quinoline-4-yloxy) acetamide-based antituberculosis agents
AF Borsoi, JD Paz, BL Abbadi, FS Macchi… - European Journal of …, 2020 - Elsevier
Using a classical molecular simplification approach, a series of 36 quinolines were
synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (M …
synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (M …
Advances in drug discovery of new antitubercular multidrug-resistant compounds
Tuberculosis (TB), a disease caused mainly by the Mycobacterium tuberculosis (Mtb), is
according to the World Health Organization (WHO) the infectious disease responsible for the …
according to the World Health Organization (WHO) the infectious disease responsible for the …
Design, synthesis and biological evaluation of (Quinazoline 4-yloxy) acetamide and (4-oxoquinazoline-3 (4H)-yl) acetamide derivatives as inhibitors of Mycobacterium …
New chemical scaffolds with novel mechanism of action are urgently needed for the
treatment of drug resistant tuberculosis. The oxidative phosphorylation pathway of …
treatment of drug resistant tuberculosis. The oxidative phosphorylation pathway of …