The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

TB being one of the deadliest diseases and second most common infectious cause of
deaths, poses the severe threat to global health. The extended duration of therapy owing to …

Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study
the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis …

New drugs with new mechanisms of action are urgently required to tackle the global
tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Cytochrome bd (Cyt-bd) oxidase, one of the two terminal oxidases in the Mycobacterium
tuberculosis (Mtb) oxidative phosphorylation pathway, plays an indispensable role in …

The global epidemic of tuberculosis (TB) imposes a sustained epidemiologic vigilance and
investments in research by governments. Mycobacterium tuberculosis, the main causative …

Using a classical molecular simplification approach, a series of 36 quinolines were
synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (M …

Tuberculosis (TB), a disease caused mainly by the Mycobacterium tuberculosis (Mtb), is
according to the World Health Organization (WHO) the infectious disease responsible for the …

New chemical scaffolds with novel mechanism of action are urgently needed for the
treatment of drug resistant tuberculosis. The oxidative phosphorylation pathway of …