Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …

Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer
therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using …

Glioblastoma (GBM), the most aggressive form of brain cancer, has witnessed very little
clinical progress over the last decades, in part, due to the absence of effective drug delivery …

In recent years, polymeric nanoparticles have appeared as a most viable and versatile
delivery system for targeted cancer therapy. Various in vivo studies have demonstrated that …

In recent years, tremendous advancements in nanomedicine have resulted in the rapid
development of various nanoformulations, especially the treatment of solid tumors. Despite …

For many years, different probing techniques have mainly relied on antibodies for molecular
recognition. However, with the discovery of aptamers, this has changed. The science …

Abstract Poly-ε-caprolactone (PCL) has been the subject of extensive research in the past
few years. It is widely explored in drug delivery, where the development of nanomedicines …

One hundred years ago, Dr. Paul Ehrlich popularized the" magic bullet" concept for cancer
therapy in which an ideal therapeutic agent would only kill the specific tumor cells it targeted …

The treatment of glioma is a great challenge because of the existence of the blood-brain
barrier (BBB). In order to reduce toxicity to the normal brain tissue and achieve efficient …

Chemotherapy for brain glioma has been of limited benefit due to the inability of drugs to
penetrate the blood–brain barrier (BBB) and non-selective drug accumulation in the entire …