Background and Objective: Rheumatoid arthritis (RA) is a predominant inflammatory
autoimmune disorder. The incidence and prevalence of RA is increasing with considerable …

The accumulation of DNA in the cytosol serves as a key immunostimulatory signal
associated with infections, cancer and genomic damage,. Cytosolic DNA triggers immune …

Noninfectious arthritis (NIA) comprises a class of chronic and progressive inflammatory
disorders that require early‐stage management to prevent disease progression. The most …

The immune system maintains homeostasis and protects the body from pathogens, mutated
cells, and other harmful substances. When immune homeostasis is disrupted, excessive …

In this study, fucoidan/chitosan nanoparticles were developed for the topical delivery of
methotrexate towards the treatment of skin-related inflammatory diseases. Based on the …

Rheumatoid arthritis (RA) is a systemic, chronic autoimmune disease that causes disability
due to progressive inflammation and destruction of the tissues around the joints …

Methotrexate (MTX) is a widely used chemotherapeutic agent; nevertheless, the
nephrotoxicity associated with its use has limited its clinical use. Rebamipide (REB) is a …

Psoriasis is reported to be a common chronic immune-mediated skin disease characterized
by abnormal keratinocytes and cell proliferation. Perilla leaves are rich in essential oils, fatty …

Magnesium isoglycyrrhizinate (MgIG), which has been widely employed to treat chronic
hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese …

We examined the effect of protocatechuic acid (PCA) on methotrexate (MTX)‐induced
testicular and epididymal toxicity in Wistar rats, treated with MTX (20 mg/kg) alone or in …