[HTML][HTML] An overview of recent technological developments in bovine genomics

NG Hossein-Zadeh - Veterinary and Animal Science, 2024 - Elsevier
Cattle are regarded as highly valuable animals because of their milk, beef, dung, fur, and
ability to draft. The scientific community has tried a number of strategies to improve the …

A cattle graph genome incorporating global breed diversity

A Talenti, J Powell, JD Hemmink, EAJ Cook… - Nature …, 2022 - nature.com
Despite only 8% of cattle being found in Europe, European breeds dominate current genetic
resources. This adversely impacts cattle research in other important global cattle breeds …

Novel functional sequences uncovered through a bovine multiassembly graph

D Crysnanto, AS Leonard, ZH Fang… - Proceedings of the …, 2021 - National Acad Sciences
Many genomic analyses start by aligning sequencing reads to a linear reference genome.
However, linear reference genomes are imperfect, lacking millions of bases of unknown …

Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies

AS Leonard, D Crysnanto, ZH Fang, MP Heaton… - Nature …, 2022 - nature.com
Advantages of pangenomes over linear reference assemblies for genome research have
recently been established. However, potential effects of sequence platform and assembly …

The Bovine Pangenome Consortium: democratizing production and accessibility of genome assemblies for global cattle breeds and other bovine species

TPL Smith, DM Bickhart, D Boichard, AJ Chamberlain… - Genome biology, 2023 - Springer
Abstract The Bovine Pangenome Consortium (BPC) is an international collaboration
dedicated to the assembly of cattle genomes to develop a more complete representation of …

[HTML][HTML] Symposium review: Advances in sequencing technology herald a new frontier in cattle genomics and genome-enabled selection

DM Bickhart, JC McClure, RD Schnabel, BD Rosen… - Journal of dairy …, 2020 - Elsevier
The cattle reference genome assembly has underpinned major innovations in beef and
dairy genetics through genome-enabled selection, including removal of deleterious …

Assessing genomic diversity and signatures of selection in Original Braunvieh cattle using whole-genome sequencing data

M Bhati, NK Kadri, D Crysnanto, H Pausch - BMC genomics, 2020 - Springer
Background Autochthonous cattle breeds are an important source of genetic variation
because they might carry alleles that enable them to adapt to local environment and food …

Bovine breed-specific augmented reference graphs facilitate accurate sequence read mapping and unbiased variant discovery

D Crysnanto, H Pausch - Genome biology, 2020 - Springer
Background The current bovine genomic reference sequence was assembled from a
Hereford cow. The resulting linear assembly lacks diversity because it does not contain …

Haplotype-aware pantranscriptome analyses using spliced pangenome graphs

JA Sibbesen, JM Eizenga, AM Novak, J Sirén… - Nature …, 2023 - nature.com
Pangenomics is emerging as a powerful computational paradigm in bioinformatics. This field
uses population-level genome reference structures, typically consisting of a sequence …

Activation of cryptic splicing in bovine WDR19 is associated with reduced semen quality and male fertility

M Hiltpold, G Niu, NK Kadri, D Crysnanto, ZH Fang… - PLoS …, 2020 - journals.plos.org
Cattle are ideally suited to investigate the genetics of male reproduction, because semen
quality and fertility are recorded for all ejaculates of artificial insemination bulls. We analysed …