Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies
BACKGROUND With increasing significance of developmental programming effects
associated with placental dysfunction, more investigations are devoted to improving the …
associated with placental dysfunction, more investigations are devoted to improving the …
Single-cell immunobiology of the maternal–fetal interface
Pregnancy success requires constant dialogue between the mother and developing
conceptus. Such crosstalk is facilitated through complex interactions between maternal and …
conceptus. Such crosstalk is facilitated through complex interactions between maternal and …
Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing
Labor is a complex physiological process requiring a well-orchestrated dialogue between
the mother and fetus. However, the cellular contributions and communications that facilitate …
the mother and fetus. However, the cellular contributions and communications that facilitate …
Human placental endothelial cell and trophoblast heterogeneity and differentiation revealed by single-cell RNA sequencing
H Li, H Peng, W Hong, Y Wei, H Tian, X Huang, L Jia… - Cells, 2022 - mdpi.com
Background: The placenta is an important organ for fetal and maternal health during
pregnancy and impacts offspring health late in life. Defects in placental vasculature and …
pregnancy and impacts offspring health late in life. Defects in placental vasculature and …
Placenta: an old organ with new functions
S Khorami-Sarvestani, N Vanaki, S Shojaeian… - Frontiers in …, 2024 - frontiersin.org
The transition from oviparity to viviparity and the establishment of feto-maternal
communications introduced the placenta as the major anatomical site to provide nutrients …
communications introduced the placenta as the major anatomical site to provide nutrients …
Accessing the human trophoblast stem cell state from pluripotent and somatic cells
Trophoblasts are specialized epithelial cells that perform critical functions during blastocyst
implantation and mediate maternal–fetal communication during pregnancy. However, our …
implantation and mediate maternal–fetal communication during pregnancy. However, our …
Human trophoblast stem cells restrict human cytomegalovirus replication
TB Rollman, ZW Berkebile, H Okae… - Journal of …, 2024 - Am Soc Microbiol
Placental infection plays a central role in the pathogenesis of congenital human
cytomegalovirus (HCMV) infections and is a cause of fetal growth restriction and pregnancy …
cytomegalovirus (HCMV) infections and is a cause of fetal growth restriction and pregnancy …
The GATA transcriptional program dictates cell fate equilibrium to establish the maternal–fetal exchange interface and fetal development
The placenta establishes a maternal–fetal exchange interface to transport nutrients and
gases between the mother and the fetus. Establishment of this exchange interface relies on …
gases between the mother and the fetus. Establishment of this exchange interface relies on …
Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model
MR Koenig, AM Mitzey, X Zeng, L Reyes… - PLoS …, 2023 - journals.plos.org
Zika virus (ZIKV) can be transmitted vertically from mother to fetus during pregnancy,
resulting in a range of outcomes including severe birth defects and fetal/infant death …
resulting in a range of outcomes including severe birth defects and fetal/infant death …
PGRMC2 and HLA-G regulate immune homeostasis in a microphysiological model of human maternal-fetal membrane interface
Chorion trophoblasts (CTCs) and immune cell-enriched decidua (DECs) comprise the
maternal-fetal membrane interface called the chorio-decidual interface (CDi) which …
maternal-fetal membrane interface called the chorio-decidual interface (CDi) which …