Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …

Intermediate filaments (IFs) constitute a major structural element of animal cells. They build
two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major …

Crystallins are the predominant structural proteins in the lens that are evolutionarily related
to stress proteins. They were first discovered outside the vertebrate eye lens by Bhat and …

Diseases of the human brain are almost universally attributed to malfunction or loss of nerve
cells. However, a considerable amount of work has, during the last decade, expanded our …

Here we review how GFAP mutations cause Alexander disease. The current data suggest
that a combination of events cause the disease. These include:(i) the accumulation of GFAP …

The proteasomal and lysosomal/autophagy pathways in the liver and other tissues are
involved in several biological processes including the degradation of misfolded proteins …

Alexander disease is a fatal neurological disorder caused by mutations in the intermediate
filament protein Glial Fibrillary Acidic Protein (GFAP), which is key for astrocyte homeostasis …

Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial
fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes. Over 70 …

Altered expression of structural and functional molecules expressed by astrocytes may play
a role in the pathophysiology of schizophrenia. We investigated the hypothesis that the …

Mutations in neurofilament light (NFL) subunit and small heat-shock protein B1 (HSPB1)
cause autosomal-dominant axonal Charcot–Marie–Tooth disease type 2E (CMT2E) and …