Celastrol in cancer therapy: Recent developments, challenges and prospects
Cancer is one of the world's biggest healthcare burdens and despite the current
advancements made in treatment plans, the outcomes for oncology patients have yet to …
advancements made in treatment plans, the outcomes for oncology patients have yet to …
Protein homeostasis in aging and cancer
XQ Chen, T Shen, SJ Fang, XM Sun, GY Li… - Frontiers in Cell and …, 2023 - frontiersin.org
Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
or proteostasis, is a universal hallmark of both the aging process and cancer, a …
Combinatorial interventions in aging
AA Parkhitko, E Filine, M Tatar - Nature Aging, 2023 - nature.com
Insight on the underlying mechanisms of aging will advance our ability to extend healthspan,
treat age-related pathology and improve quality of life. Multiple genetic and pharmacological …
treat age-related pathology and improve quality of life. Multiple genetic and pharmacological …
Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention
A Llorente, RM Loughran, BM Emerling - Frontiers in Cell and …, 2023 - frontiersin.org
Phosphoinositides serve as essential players in numerous biological activities and are
critical for overall cellular function. Due to their complex chemical structures, localization …
critical for overall cellular function. Due to their complex chemical structures, localization …
Synthetic lethality prediction in DNA damage repair, chromatin remodeling and the cell cycle using multi-omics data from cell lines and patients.
M Markowska, MA Budzinska, A Coenen-Stass… - Scientific Reports, 2023 - nature.com
Discovering synthetic lethal (SL) gene partners of cancer genes is an important step in
developing cancer therapies. However, identification of SL interactions is challenging, due …
developing cancer therapies. However, identification of SL interactions is challenging, due …
Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila
Aging is characterized by extensive metabolic dysregulation. Redox coenzyme nicotinamide
adenine dinucleotide (NAD) can exist in oxidized (NAD+) or reduced (NADH) states, which …
adenine dinucleotide (NAD) can exist in oxidized (NAD+) or reduced (NADH) states, which …
SLIDE-VIP: a comprehensive, cell line-and patient-based framework for synthetic lethality prediction in DNA damage repair, chromatin remodeling and cell cycle
M Markowska, MA Budzinska, A Coenen-Stass, S Kang… - bioRxiv, 2022 - biorxiv.org
Discovering synthetic lethal (SL) gene partners of cancer genes is an important step in
developing cancer therapies. However, identification of SL interactions is challenging, due …
developing cancer therapies. However, identification of SL interactions is challenging, due …
The role of p53 cofactor JMY in the regulation of gene expression in human tumours during DNA damage
IR Pastrana - 2023 - search.proquest.com
The tumour suppressor p53 is a nuclear transcription factor that orchestrates a myriad of
cellular pathways, including cell cycle arrest, DNA repair, and apoptosis in response to …
cellular pathways, including cell cycle arrest, DNA repair, and apoptosis in response to …