Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Lipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be
required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking …

Interactions between the brain and distinct adipose depots have a key role in maintaining
energy balance, thereby promoting survival in response to metabolic challenges such as …

The global incidence of obesity and its comorbidities continues to rise along with a demand
for novel therapeutic interventions. Brown adipose tissue (BAT) is attracting attention as a …

Brown adipose tissue (BAT) is a therapeutic target for metabolic diseases; thus,
understanding its metabolic circuitry is clinically important. Many studies of BAT compare …

Obesity and type 2 diabetes have reached pandemic proportion. ALDH2 (acetaldehyde
dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other …