Abstract Chronic Lymphocytic Leukemia (CLL) is a malignancy of mature B lymphocytes
which are highly dependent on interactions with the tissue microenvironment for their …

Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone
remarkable changes during the past decade. This review addresses the latest ideas …

Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types
of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of …

B cell receptor (BCR) signaling plays an important pathogenic role in chronic lymphocytic
leukemia (CLL) and B cell lymphomas, based on structural restrictions of the BCR, and BCR …

B-cell antigen receptor (BCR) expression is an important feature of chronic lymphocytic
leukaemia (CLL), one of the most prevalent B-cell neoplasias in Western countries. The …

Over the last decade, the active role of the microenvironment in the pathogenesis of B cell
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …

The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a
malignancy of mature B cells with a characteristic clinical presentation but a variable clinical …

We report here that in chronic lymphocytic leukemia (CLL), the propensity to generate clonal
B cells has been acquired already at the hematopoietic stem cell (HSC) stage. HSCs …

The chronic lymphocytic leukemia (CLL) immunoglobulin repertoire is biased and
characterized by the existence of subsets of cases with closely homologous (“stereotyped”) …

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although
over 100 years have passed since the discovery of Chagas disease, it still presents an …