Arginase: biological and therapeutic implications in diabetes mellitus and its complications

Y Ren, Z Li, W Li, X Fan, F Han, Y Huang… - Oxidative Medicine …, 2022 - Wiley Online Library
Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

Metabolic architecture of acute exercise response in middle-aged adults in the community

M Nayor, RV Shah, PE Miller, JB Blodgett, M Tanguay… - Circulation, 2020 - Am Heart Assoc
Background: Whereas regular exercise is associated with lower risk of cardiovascular
disease and mortality, mechanisms of exercise-mediated health benefits remain less clear …

[HTML][HTML] Targeted metabolomics analysis of amino acids and acylcarnitines as risk markers for diabetes by LC–MS/MS technique

S Hosseinkhani, B Arjmand, A Dilmaghani-Marand… - Scientific Reports, 2022 - nature.com
Diabetes is a common chronic disease affecting millions of people worldwide. It underlies
various complications and imposes many costs on individuals and society. Discovering early …

[HTML][HTML] Association of COVID-19 with hepatic metabolic dysfunction

R Kumar, V Kumar, R Arya, U Anand… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to be a global
problem with over 438 million cases reported so far. Although it mostly affects the respiratory …

Neuroprotective protein hydrolysates from hemp (Cannabis sativa L.) seeds

NM Rodriguez-Martin, R Toscano, A Villanueva… - Food & function, 2019 - pubs.rsc.org
Hemp (Cannabis sativa L.) seeds are well known for their potential use as a source of
nutrients, fiber, and bioactive compounds. A hemp protein isolate, prepared from defatted …

[HTML][HTML] Plant protein reduces serum cholesterol levels in hypercholesterolemia hamsters by modulating the compositions of gut microbiota and metabolites

LT Tong, T Xiao, L Wang, C Lu, L Liu, X Zhou, A Wang… - Iscience, 2021 - cell.com
Plant proteins exert effects of reducing cardio-cerebrovascular disease-related mortality
partly via cholesterol-lowering, which was associated with gut microbiota. Here, we verify …

Serum acylcarnitines and amino acids and risk of type 2 diabetes in a multiethnic Asian population

SH Gunther, CM Khoo, ES Tai, X Sim… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Introduction We evaluated whether concentrations of serum acylcarnitines and amino acids
are associated with risk of type 2 diabetes and can improve predictive diabetes models in an …

Gut microbiome of a porcine model of metabolic syndrome and HF-pEF

AN O'Donovan, FM Herisson, F Fouhy… - American Journal …, 2020 - journals.physiology.org
Metabolic syndrome (MetS) is a composite of cardiometabolic risk factors, including obesity,
dyslipidemia, hypertension, and insulin resistance, with a range of secondary sequelae such …

[HTML][HTML] Hemp protein hydrolysates modulate inflammasome-related genes in microglial cells

S Montserrat-De la Paz, G Carrillo-Berdasco… - Biology, 2022 - mdpi.com
Simple Summary Neuroinflammation can lead to the development of neurodegenerative
diseases. Food-derived peptides released by the action of enzymes have been proven to …

Metabolomics approach to male lower urinary tract symptoms: identification of possible biomarkers and potential targets for new treatments

T Mitsui, S Kira, T Ihara, N Sawada, H Nakagomi… - The Journal of …, 2018 - Elsevier
Purpose We identified metabolites using a metabolomics approach and investigated the
association between these metabolites and lower urinary tract symptoms. Materials and …