Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic
units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia …

Introduction: B cell lymphoma 6 (BCL6) is a transcriptional repressor critical for the
development and maintenance of germinal centers (GCs), which are required for generation …

Background & Aims Long non-coding RNAs (lncRNAs) are expressed in tissue-specific
pattern, but it is not clear how these are regulated. We aimed to identify squamous cell …

Mutational activation of KRAS is a common oncogenic event in lung cancer, yet effective
therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in …

Abstract Altered expression of Urea Cycle (UC) enzymes occurs in many tumors, resulting a
metabolic hallmark termed as UC dysregulation. Polyamines are synthesized from ornithine …

Abstract B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first
identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor …

B-cell lymphoma 6 (BCL6) is a transcriptional repressor that regulates the differentiation of B
lymphocytes and mediates the formation of germinal centers (GCs) by recruiting …

The bromodomain and extra-terminal domain (BET) proteins are promising therapeutic
targets to treat refractory solid tumors; however, inherent resistance remains a major …