What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

AM Fjell, L McEvoy, D Holland, AM Dale… - Progress in …, 2014 - Elsevier
What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

Alzheimer disease

DS Knopman, H Amieva, RC Petersen… - Nature reviews Disease …, 2021 - nature.com
Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

Deep learning encodes robust discriminative neuroimaging representations to outperform standard machine learning

A Abrol, Z Fu, M Salman, R Silva, Y Du, S Plis… - Nature …, 2021 - nature.com
Recent critical commentaries unfavorably compare deep learning (DL) with standard
machine learning (SML) approaches for brain imaging data analysis. However, their …

Neuroimaging of language control in bilinguals: neural adaptation and reserve

J Abutalebi, DW Green - Bilingualism: Language and cognition, 2016 - cambridge.org
Speaking more than one language demands a language control system that allows
bilinguals to correctly use the intended language adjusting for possible interference from the …

The clinical use of structural MRI in Alzheimer disease

GB Frisoni, NC Fox, CR Jack Jr, P Scheltens… - Nature reviews …, 2010 - nature.com
Structural imaging based on magnetic resonance is an integral part of the clinical
assessment of patients with suspected Alzheimer dementia. Prospective data on the natural …

Structural brain changes in aging: courses, causes and cognitive consequences

AM Fjell, KB Walhovd - Reviews in the Neurosciences, 2010 - degruyter.com
The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

Automatic classification of patients with Alzheimer's disease from structural MRI: a comparison of ten methods using the ADNI database

R Cuingnet, E Gerardin, J Tessieras, G Auzias… - neuroimage, 2011 - Elsevier
Recently, several high dimensional classification methods have been proposed to
automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive …

[HTML][HTML] Longitudinal association between hippocampus atrophy and episodic-memory decline

T Gorbach, S Pudas, A Lundquist, G Orädd… - Neurobiology of …, 2017 - Elsevier
There is marked variability in both onset and rate of episodic-memory decline in aging.
Structural magnetic resonance imaging studies have revealed that the extent of age-related …

One-year brain atrophy evident in healthy aging

AM Fjell, KB Walhovd… - Journal of …, 2009 - Soc Neuroscience
An accurate description of changes in the brain in healthy aging is needed to understand the
basis of age-related changes in cognitive function. Cross-sectional magnetic resonance …

Alzheimer's disease: etiology, neuropathology and pathogenesis

O Sheppard, M Coleman - Exon Publications, 2020 - exonpublications.com
Alzheimer's disease is the most common form of dementia and the most common
neurodegenerative disease. It manifests as a decline in short-term memory and cognition …