Neurofibromatosis type 1 is a complex autosomal dominant disorder caused by germline
mutations in the NF1 tumour suppressor gene. Nearly all individuals with neurofibromatosis …

Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

During tumorigenesis, tumors must evolve to evade the immune system and do so by
disrupting the genes involved in antigen processing and presentation or up-regulating …

Neurofibromatosis type 1 is a relatively common inherited disorder. Patients have a high
predisposition to develop both benign and malignant tumours. Although many …

Abstract Neurofibromatosis type 1 (NF1) is a common genetic disorder that predisposes
affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein …

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …

The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types.
However, loss-of-function mutations in PRC2 components occur in a subset of …

Learning Objectives Explain the characteristics and treatment of malignant peripheral nerve
sheath tumors, both in relation to neurofibromatosis type I and otherwise. Cite the unique …

Human tumors often display changes in DNA methylation, including both genome-wide
hypomethylation and site-specific hypermethylation (1, 2). In mice, DNA hypomethylation is …

Animal models of cancer provide an alternative means to determine the causes of and
treatments for malignancy, thus representing a resource of immense potential for cancer …