Role of extracellular matrix in development and cancer progression

C Walker, E Mojares, A del Río Hernández - International journal of …, 2018 - mdpi.com
The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …

Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies

R Mhaidly, F Mechta-Grigoriou - Seminars in immunology, 2020 - Elsevier
Abstract In tumors, Cancer-Associated Fibroblasts (CAFs) constitute the most prominent
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …

Cancer associated fibroblasts: An essential role in the tumor microenvironment

L Tao, G Huang, H Song, Y Chen… - Oncology …, 2017 - spandidos-publications.com
Fibroblasts in the tumor stroma are well recognized as having an indispensable role in
carcinogenesis, including in the initiation of epithelial tumor formation. The association …

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

C Gialeli, AD Theocharis, NK Karamanos - The FEBS journal, 2011 - Wiley Online Library
Matrix metalloproteinases (MMPs) consist of a multigene family of zinc‐dependent
extracellular matrix (ECM) remodeling endopeptidases implicated in pathological …

Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry

A Mucha, P Kafarski, Ł Berlicki - Journal of Medicinal Chemistry, 2011 - ACS Publications
R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

[HTML][HTML] Matrix metalloproteinases: fold and function of their catalytic domains

C Tallant, A Marrero, FX Gomis-Rüth - Biochimica et Biophysica Acta (BBA) …, 2010 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent protein and peptide hydrolases. They
have been almost exclusively studied in vertebrates and 23 paralogs are present in humans …

Matrix metalloproteinases

O Zítka, J Kukacka, S Krizkov, D Húska… - Current medicinal …, 2010 - ingentaconnect.com
Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-
dependent proteins, which are thought to play a central role in the breakdown of …

Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes

D Sbardella, GF Fasciglione, M Gioia, C Ciaccio… - Molecular aspects of …, 2012 - Elsevier
Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Multitargeted therapy of cancer by green tea polyphenols

N Khan, H Mukhtar - Cancer letters, 2008 - Elsevier
Tea ranks second only to water as a major component of fluid intake worldwide and has
been considered a health-promoting beverage since ancient times. For the past two …

The behavior of matrix metalloproteinases and their inhibitors in colorectal cancer

L Herszényi, I Hritz, G Lakatos, MZ Varga… - International journal of …, 2012 - mdpi.com
Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular
matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled …