Role of extracellular matrix in development and cancer progression
C Walker, E Mojares, A del Río Hernández - International journal of …, 2018 - mdpi.com
The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …
Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies
R Mhaidly, F Mechta-Grigoriou - Seminars in immunology, 2020 - Elsevier
Abstract In tumors, Cancer-Associated Fibroblasts (CAFs) constitute the most prominent
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …
Cancer associated fibroblasts: An essential role in the tumor microenvironment
Fibroblasts in the tumor stroma are well recognized as having an indispensable role in
carcinogenesis, including in the initiation of epithelial tumor formation. The association …
carcinogenesis, including in the initiation of epithelial tumor formation. The association …
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
Matrix metalloproteinases (MMPs) consist of a multigene family of zinc‐dependent
extracellular matrix (ECM) remodeling endopeptidases implicated in pathological …
extracellular matrix (ECM) remodeling endopeptidases implicated in pathological …
Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry
R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …
[HTML][HTML] Matrix metalloproteinases: fold and function of their catalytic domains
C Tallant, A Marrero, FX Gomis-Rüth - Biochimica et Biophysica Acta (BBA) …, 2010 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent protein and peptide hydrolases. They
have been almost exclusively studied in vertebrates and 23 paralogs are present in humans …
have been almost exclusively studied in vertebrates and 23 paralogs are present in humans …
Matrix metalloproteinases
O Zítka, J Kukacka, S Krizkov, D Húska… - Current medicinal …, 2010 - ingentaconnect.com
Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-
dependent proteins, which are thought to play a central role in the breakdown of …
dependent proteins, which are thought to play a central role in the breakdown of …
Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes
D Sbardella, GF Fasciglione, M Gioia, C Ciaccio… - Molecular aspects of …, 2012 - Elsevier
Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
Multitargeted therapy of cancer by green tea polyphenols
N Khan, H Mukhtar - Cancer letters, 2008 - Elsevier
Tea ranks second only to water as a major component of fluid intake worldwide and has
been considered a health-promoting beverage since ancient times. For the past two …
been considered a health-promoting beverage since ancient times. For the past two …
The behavior of matrix metalloproteinases and their inhibitors in colorectal cancer
L Herszényi, I Hritz, G Lakatos, MZ Varga… - International journal of …, 2012 - mdpi.com
Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular
matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled …
matrix components crucial for tumor growth, invasion and metastasis. MMPs are controlled …