Abstract Mesenchymal Stem Cells (MSCs) have been studied extensively for the treatment
of several retinal diseases. The therapeutic potential of MSCs lies in its ability to differentiate …

MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane
of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment …

Retinitis Pigmentosa (RP) is a group of inherited retinal diseases characterized by
progressive loss of rod followed by cone photoreceptors. An especially early onset form of …

Introduction The vertebrate retinal pigment epithelium (RPE) lies adjacent to the
photoreceptors and is responsible for the engulfment and degradation of shed …

The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical
contact site between the ER and the mitochondria and plays a vital role in the regulation of …

Gene therapy has been one of the most researched topics in the last decade. It has now
become a revolutionized therapeutic tool of modern medicine. Gene therapy is the alteration …

Inhibiting MerTK on macrophages is a promising therapeutic strategy for augmenting anti-
tumor immunity. However, blocking MerTK on retinal pigment epithelial cells (RPEs) results …

The present study aimed to evaluate the effects of NK-4 on the apoptosis of photoreceptors
in a rat model of retinitis pigmentosa and explore the mechanism underlying anti-apoptosis …

Inherited retinal diseases (IRDs) are a leading cause of irreversible visual loss in the
developed world. The primary driver of pathology in IRDs is pathogenic genetic variant …

Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by
progressive development of kidney cysts and enlargement and dysfunction of the kidneys …