Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …

SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with
various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop …

Efficient repair of DNA double-strand breaks (DSBs) requires a coordinated DNA Damage
Response (DDR), which includes phosphorylation of histone H2Ax, forming γH2Ax. This …

Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …

When DNA damage, whether it is endogenous or exogenous, forms double stranded breaks
(DSBs), it is always followed by the phosphorylation of the histone, H2AX. H2AX is a variant …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

Despite a conserved role for histones as general DNA packaging agents, it is now clear that
another key function of these proteins is to confer variations in chromatin structure to ensure …