Metaplasia: tissue injury adaptation and a precursor to the dysplasia–cancer sequence
V Giroux, AK Rustgi - Nature Reviews Cancer, 2017 - nature.com
Metaplasia is the replacement of one differentiated somatic cell type with another
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …
differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by …
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
INTRODUCTION The association between tumors and inflammation is a long-established
clinical observation. Although many studies have demonstrated that the inflammatory …
clinical observation. Although many studies have demonstrated that the inflammatory …
Acinar to ductal cell trans-differentiation: A prelude to dysplasia and pancreatic ductal adenocarcinoma
Pancreatic cancer (PC) is the deadliest neoplastic epithelial malignancies and is projected
to be the second leading cause of cancer-related mortality by 2024. Five years overall …
to be the second leading cause of cancer-related mortality by 2024. Five years overall …
Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer
Y Li, Y He, J Peng, Z Su, Z Li, B Zhang, J Ma, M Zhuo… - Nature Cancer, 2021 - nature.com
Kras-activating mutations display the highest incidence in pancreatic ductal
adenocarcinoma. Pancreatic inflammation accelerates mutant Kras-driven tumorigenesis in …
adenocarcinoma. Pancreatic inflammation accelerates mutant Kras-driven tumorigenesis in …
Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer
Inflammation is strongly associated with pancreatic ductal adenocarcinoma (PDAC), a highly
lethal malignancy. Dysregulated RNA splicing factors have been widely reported in …
lethal malignancy. Dysregulated RNA splicing factors have been widely reported in …
[HTML][HTML] Interleukin 22 signaling regulates acinar cell plasticity to promote pancreatic tumor development in mice
Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is an aggressive
malignancy that invades surrounding structures and metastasizes rapidly. Although …
malignancy that invades surrounding structures and metastasizes rapidly. Although …
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
While adult pancreatic stem cells are thought not to exist, it is now appreciated that the
acinar compartment harbors progenitors, including tissue-repairing facultative progenitors …
acinar compartment harbors progenitors, including tissue-repairing facultative progenitors …
Krüppel-like factor 5, increased in pancreatic ductal adenocarcinoma, promotes proliferation, acinar-to-ductal metaplasia, pancreatic intraepithelial neoplasia, and …
P He, JW Yang, VW Yang, AB Bialkowska - Gastroenterology, 2018 - Elsevier
Background & Aims Activating mutations in KRAS are detected in most pancreatic ductal
adenocarcinomas (PDACs). Expression of an activated form of KRAS (KrasG12D) in …
adenocarcinomas (PDACs). Expression of an activated form of KRAS (KrasG12D) in …
Signaling networks that control cellular plasticity in pancreatic tumorigenesis, progression, and metastasis
HC Crawford, MP di Magliano, S Banerjee - Gastroenterology, 2019 - Elsevier
Pancreatic ductal adenocarcinoma is one of the deadliest cancers, and its incidence on the
rise. The major challenges in overcoming the poor prognosis with this disease include late …
rise. The major challenges in overcoming the poor prognosis with this disease include late …
Metabolism and epigenetics of pancreatic cancer stem cells
MP Lanfranca, JK Thompson, F Bednar… - Seminars in cancer …, 2019 - Elsevier
Pancreatic Cancer (PDA) is an aggressive malignancy characterized by early spread and a
high mortality. Current studies suggest that a subpopulation of cells exist within tumors …
high mortality. Current studies suggest that a subpopulation of cells exist within tumors …