Heat shock proteins (HSP) are expressed at high levels in cancer and form a fostering
environment that is essential for tumor development. Here, we review the recent data in this …

Extracellular heat shock proteins (ex-HSPs) have been found in exosomes, oncosomes,
membrane surfaces, as well as free HSP in cancer and various pathological conditions, also …

Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute
stress. They are best known as inducible transcriptional regulators of genes encoding …

Heat shock proteins (Hsps) are overexpressed in a wide range of human cancers and are
implicated in tumor cell proliferation, differentiation, invasion, metastasis, death, and …

Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

The heat shock proteins (HSPs) induced by cell stress are expressed at high levels in a wide
range of tumors and are closely associated with a poor prognosis and resistance to therapy …

Summary Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in
eukaryotes, a very highly conserved protective mechanism. HSF1 function increases …

Mechanistic studies from cell culture and animal models have revealed critical roles for the
heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of …

Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their
rapid and abundant induction by stress. HSP genes are activated at the transcriptional level …

Hsp60 in eukaryotes is considered typically a mitochondrial chaperone (also called Cpn60)
but in the last few years it has become clear that it also occurs in the cytosol, the cell surface …