Vitamin K‐dependent proteins require carboxylation of certain glutamates for their biological
functions. The enzymes involved in the vitamin K‐dependent carboxylation include: gamma …

Vitamin K (VK) is an essential cofactor for the post-translational conversion of peptide-bound
glutamate to γ-carboxyglutamate. The resultant vitamin K–dependent proteins are known or …

Vitamin K is a vital micronutrient implicated in a variety of human diseases. Warfarin, a
vitamin K antagonist, is the most commonly prescribed oral anticoagulant. Patients …

Vitamin K is involved many biological processes, such as the regulation of blood
coagulation, prevention of vascular calcification, bone metabolism and modulation of cell …

Vitamin K-dependent (VKD) proteins undergo an unusual post-translational modification,
which is the conversion of specific Glu residues to carboxylated Glu (Gla). Gla generation is …

Abstract Ca 2+ binding proteins (CBP) are of key importance for calcium to play its role as a
pivotal second messenger. CBP bind Ca 2+ in specific domains, contributing to the …

The goal of the Association for Molecular Pathology (AMP) Clinical Practice Committee's
AMP Pharmacogenomics (PGx) Working Group is to define the key attributes of PGx alleles …

Vascular calcification (VC), characterized by different mineral deposits (ie, carbonate apatite,
whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a …

Keutel syndrome (KS) is a rare autosomal recessive genetic disorder that was first identified
in the beginning of the 1970s and nearly 30 years later attributed to loss-of-function …

Abstract γ-Glutamyl carboxylase (GGCX) is an integral membrane protein that catalyzes
posttranslational carboxylation of a number of vitamin K–dependent (VKD) proteins involved …