Bioprocessing in the digital age: the role of process models

H Narayanan, MF Luna, M von Stosch… - Biotechnology …, 2020 - Wiley Online Library
In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

Comprehensive review on agricultural waste utilization and high-temperature fermentation and composting

Z Mengqi, A Shi, M Ajmal, L Ye, M Awais - Biomass Conversion and …, 2021 - Springer
Due to the high demand for food and meat for the world's growing population, the
agricultural sector is expanding every year. Timely and effective treatment is of utmost …

Micromixing within microfluidic devices

L Capretto, W Cheng, M Hill, X Zhang - Microfluidics: technologies and …, 2011 - Springer
Micromixing is a crucial process within microfluidic systems such as micro total analysis
systems (μTAS). A state-of-art review on microstructured mixing devices and their mixing …

Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells

A Berlec, B Štrukelj - Journal of industrial microbiology and …, 2013 - academic.oup.com
Almost all of the 200 or so approved biopharmaceuticals have been produced in one of
three host systems: the bacterium Escherichia coli, yeasts (Saccharomyces cerevisiae …

Integration and application of optical chemical sensors in microbioreactors

P Gruber, MPC Marques, N Szita, T Mayr - Lab on a Chip, 2017 - pubs.rsc.org
The quantification of key variables such as oxygen, pH, carbon dioxide, glucose, and
temperature provides essential information for biological and biotechnological applications …

A review of advanced small‐scale parallel bioreactor technology for accelerated process development: Current state and future need

R Bareither, D Pollard - Biotechnology progress, 2011 - Wiley Online Library
The pharmaceutical and biotech industries face continued pressure to reduce development
costs and accelerate process development. This challenge occurs alongside the need for …

Scale-down simulators for metabolic analysis of large-scale bioprocesses

P Neubauer, S Junne - Current opinion in biotechnology, 2010 - Elsevier
Analytical approaches for a comprehensive understanding of the metabolic networks in
microbial cultures are mostly based on small-scale cultures which are in a steady state or …

Novel mutagenesis and screening technologies for food microorganisms: advances and prospects

Q Yu, Y Li, B Wu, W Hu, M He, G Hu - Applied microbiology and …, 2020 - Springer
Microorganisms are indispensable in the food industry, but wild-type strains hardly meet the
current industrial demands due to several undesirable traits. Therefore, microbial strain …

Experimental methods and modeling techniques for description of cell population heterogeneity

RL Fernandes, M Nierychlo, L Lundin… - Biotechnology …, 2011 - Elsevier
With the continuous development, in the last decades, of analytical techniques providing
complex information at single cell level, the study of cell heterogeneity has been the focus of …

The development and application of high throughput cultivation technology in bioprocess development

Q Long, X Liu, Y Yang, L Li, L Harvey, B McNeil… - Journal of …, 2014 - Elsevier
This review focuses on recent progress in the technology of high throughput (HTP)
cultivation and its increasing application in quality by design (QbD)-driven bioprocess …