Cancer is a complex disease involving numerous biological processes, which can exist in
parallel, can be complementary, or are engaged when needed and as such can replace …

Inflammation is part of our body's response to tissue injury and pathogens. It helps to recruit
various immune cells to the site of inflammation and activates the production of mediators to …

As a critical sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays an essential role
in immune and vascular systems. There are five S1P receptors, designated as S1PR1 to …

Sphingosine 1‐phosphate (S1P) is a bioactive lipid that binds to a family of G protein‐
coupled receptors (S1P1–5) and intracellular targets, such as HDAC1/2, that are functional …

The world is currently experiencing the worst health pandemic since the Spanish flu in 1918—
the COVID-19 pandemic—caused by the coronavirus severe acute respiratory syndrome …

The various sphingosine kinase (SphK) isoenzymes (isozymes) and isoforms, key players in
normal cellular physiology, are strongly implicated in cancer and other diseases. Mutations …

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic
cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways …

Conventional chemotherapy-based drug combinations have, until recently, been the
backbone of most therapeutic strategies for cancer. In a time of emerging rationale drug …

Huntington disease (HD) is a debilitating, currently incurable disease. Protein aggregation
and metabolic deficits are pathological hallmarks but their link to neurodegeneration and …

Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, the third leading
cause of cancer-associated death worldwide. With the increasing prevalence of metabolic …