Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …

Gliomas represent the most common type of malignant brain tumor, among which,
glioblastoma remains a clinical challenge with limited treatment options and dismal …

Abnormal energy metabolism, as one of the important hallmarks of cancer, was induced by
multiple carcinogenic factors and tumor-specific microenvironments. It comprises aerobic …

As is known to all, glioma, a global difficult problem, has a high malignant degree, high
recurrence rate and poor prognosis. We analyzed and summarized signal pathway of the …

Abstract Histone deacetylase 6 (HDAC6) activity contributes to the malignant proliferation,
invasion, and migration of glioma cells (GCs), but the molecular mechanisms underlying the …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. It is a
devastating and intractable disease with a poor outcome. Aberrant receptor tyrosine kinase …

Our most recent studies demonstrate that Rho GDI β is able to promote human bladder
cancer (BC) invasion and metastasis in an X‐link inhibitor of apoptosis protein‐dependent …

JNK activity has been implicated in the malignant proliferation, invasion and drug‐resistance
of glioma cells (GCs), but the molecular mechanisms underlying JNK activation are currently …

Malignant cancer cells can invade extracellular matrix (ECM) through the formation of F-
actin-rich subcellular structures termed invadopodia. ECM degradation at invadopodia is …

Pediatric high-grade gliomas (pHGG) accounts for approximately 8–12% of primary brain
tumors in children. Prognosis is poor, with a median survival of 9–15 months. Insulin-like …