Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism
Autophagy is a fundamental catabolic process coordinated by a network of autophagy-
related (ATG) proteins. These ATG proteins also perform an important parallel role in …
related (ATG) proteins. These ATG proteins also perform an important parallel role in …
Approved antiviral drugs over the past 50 years
E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …
categorized into 13 functional groups have been formally approved for the treatment of the …
Inhibitors of the M2 proton channel engage and disrupt transmembrane networks of hydrogen-bonded waters
JL Thomaston, NF Polizzi, A Konstantinidi… - Journal of the …, 2018 - ACS Publications
Water-mediated interactions play key roles in drug binding. In protein sites with sparse polar
functionality, a small-molecule approach is often viewed as insufficient to achieve high …
functionality, a small-molecule approach is often viewed as insufficient to achieve high …
Salt-excluding artificial water channels exhibiting enhanced dipolar water and proton translocation
Aquaporins (AQPs) are biological water channels known for fast water transport (∼ 108–
109 molecules/s/channel) with ion exclusion. Few synthetic channels have been designed …
109 molecules/s/channel) with ion exclusion. Few synthetic channels have been designed …
Acid activation mechanism of the influenza A M2 proton channel
The homotetrameric influenza A M2 channel (AM2) is an acid-activated proton channel
responsible for the acidification of the influenza virus interior, an important step in the viral …
responsible for the acidification of the influenza virus interior, an important step in the viral …
High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction
JL Thomaston, M Alfonso-Prieto… - Proceedings of the …, 2015 - National Acad Sciences
The matrix 2 (M2) protein from influenza A virus is a proton channel that uses His37 as a
selectivity filter. Here we report high-resolution (1.10 Å) cryogenic crystallographic structures …
selectivity filter. Here we report high-resolution (1.10 Å) cryogenic crystallographic structures …
Voltage and pH sensing by the voltage-gated proton channel, HV1
TE DeCoursey - Journal of the Royal Society Interface, 2018 - royalsocietypublishing.org
Voltage-gated proton channels are unique ion channels, membrane proteins that allow
protons but no other ions to cross cell membranes. They are found in diverse species, from …
protons but no other ions to cross cell membranes. They are found in diverse species, from …
Proton movement and coupling in the POT family of peptide transporters
POT transporters represent an evolutionarily well-conserved family of proton-coupled
transport systems in biology. An unusual feature of the family is their ability to couple the …
transport systems in biology. An unusual feature of the family is their ability to couple the …
XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction
JL Thomaston, RA Woldeyes… - Proceedings of the …, 2017 - National Acad Sciences
The M2 proton channel of influenza A is a drug target that is essential for the reproduction of
the flu virus. It is also a model system for the study of selective, unidirectional proton …
the flu virus. It is also a model system for the study of selective, unidirectional proton …
A quantitative paradigm for water-assisted proton transport through proteins and other confined spaces
Water-assisted proton transport through confined spaces influences many phenomena in
biomolecular and nanomaterial systems. In such cases, the water molecules that fluctuate in …
biomolecular and nanomaterial systems. In such cases, the water molecules that fluctuate in …