Neurotoxicity of methamphetamine and 3, 4-methylenedioxymethamphetamine

LE Halpin, SA Collins, BK Yamamoto - Life sciences, 2014 - Elsevier
Amphetamines are a class of psychostimulant drugs that are widely abused for their
stimulant, euphoric, empathogenic and hallucinogenic properties. Many of these effects …

Mechanisms of action and persistent neuroplasticity by drugs of abuse

ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015 - ASPET
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Amphetamine toxicities: classical and emerging mechanisms

BK Yamamoto, A Moszczynska… - Annals of the New York …, 2010 - Wiley Online Library
The drugs of abuse, methamphetamine and MDMA, produce long‐term decreases in
markers of biogenic amine neurotransmission. These decreases have been traditionally …

Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview

JP Capela, H Carmo, F Remião, ML Bastos… - Molecular …, 2009 - Springer
Abstract “Ecstasy”[(±)-3, 4-methylenedioxymethamphetamine, MDMA, XTC, X, E] is a
psychoactive recreational hallucinogenic substance and a major worldwide drug of abuse …

Causes and consequences of methamphetamine and MDMA toxicity

MS Quinton, BK Yamamoto - The AAPS journal, 2006 - Springer
Methamphetamine (METH) and its derivative 3, 4-methylenedioxymethamphetamine
(MDMA; ecstasy) are 2 substituted amphetamines with very high abuse liability in the United …

The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse

BK Yamamoto, J Raudensky - Journal of Neuroimmune Pharmacology, 2008 - Springer
Abstract Methamphetamine (METH) and 3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) are amphetamine derivatives with high abuse liability. These amphetamine-related …

Actions of 3, 4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons

GA Gudelsky, BK Yamamoto - Pharmacology Biochemistry and Behavior, 2008 - Elsevier
3, 4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative and a
popular drug of abuse that exhibits mild hallucinogenic and rewarding properties and …

Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51

HS Sharma, PO Sjoquist, SF Ali - Current pharmaceutical …, 2007 - ingentaconnect.com
The psychostimulants, morphine and methamphetamine are well known drugs of abuse that
induce brain pathology and/or neurodegeneration resulting in a huge burden on our society …

Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage

BJ Song, KH Moon, VV Upreti… - Current …, 2010 - ingentaconnect.com
Despite numerous reports about the acute and sub-chronic toxicities caused by MDMA (3, 4-
methylenedioxymethamphetamine, ecstasy), the underlying mechanism of organ damage is …

Ecstasy induces apoptosis via 5-HT2A-receptor stimulation in cortical neurons

JP Capela, E Fernandes, F Remião, ML Bastos… - Neurotoxicology, 2007 - Elsevier
3, 4-Methylenedioxymethamphetamine (MDMA or “Ecstasy”) is a psychoactive and
hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in …