The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
The role of amyloid-β oligomers in toxicity, propagation, and immunotherapy
U Sengupta, AN Nilson, R Kayed - EBioMedicine, 2016 - thelancet.com
The incidence of Alzheimer's disease (AD) is growing every day and finding an effective
treatment is becoming more vital. Amyloid-β (Aβ) has been the focus of research for several …
treatment is becoming more vital. Amyloid-β (Aβ) has been the focus of research for several …
A vicious cycle of β amyloid–dependent neuronal hyperactivation
β-amyloid (Aβ)–dependent neuronal hyperactivity is believed to contribute to the circuit
dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although …
dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although …
Large soluble oligomers of amyloid β-protein from Alzheimer brain are far less neuroactive than the smaller oligomers to which they dissociate
Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains of Alzheimer's disease
(AD) patients have been shown experimentally (in the absence of amyloid plaques) to …
(AD) patients have been shown experimentally (in the absence of amyloid plaques) to …
[HTML][HTML] Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains
Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in
supernatants following ultracentrifugation of aqueous extracts from Alzheimer's disease (AD) …
supernatants following ultracentrifugation of aqueous extracts from Alzheimer's disease (AD) …
The toxicity and polymorphism of β-amyloid oligomers
Y Huang, R Liu - International journal of molecular sciences, 2020 - mdpi.com
It is widely accepted that β-amyloid oligomers (Aβos) play a key role in the progression of
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins
Neurodegenerative diseases are an enormous public health problem, affecting tens of
millions of people worldwide. Nearly all of these diseases are characterized by …
millions of people worldwide. Nearly all of these diseases are characterized by …
Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane
Mounting evidence suggests that the neuronal cell membrane is the main site of oligomer-
mediated neuronal toxicity of amyloid-β peptides in Alzheimer's disease. To gain a detailed …
mediated neuronal toxicity of amyloid-β peptides in Alzheimer's disease. To gain a detailed …
Amyloid β-protein and beyond: the path forward in Alzheimer's disease
DM Walsh, DJ Selkoe - Current opinion in neurobiology, 2020 - Elsevier
Highlights•Lack of success of most anti-amyloid trials in symptomatic AD is attributable in
part to the pathology being too advanced.•Progress in quantifying tau and Aβ in plasma …
part to the pathology being too advanced.•Progress in quantifying tau and Aβ in plasma …
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain
Significant data suggest that soluble Aβ oligomers play an important role in Alzheimer's
disease (AD), but there is great confusion over what exactly constitutes an Aβ oligomer and …
disease (AD), but there is great confusion over what exactly constitutes an Aβ oligomer and …