The prevention and treatment of obesity is primary based on the follow-up of a healthy
lifestyle, which includes a healthy diet with an important presence of bioactive compounds …

The growing interest in anticancer hybrids in the last few years has resulted in a great
number of reports on hybrid design, synthesis and bioevaluation. Many novel multi-target …

Background The gut microbiota contributes to macrophage-mediated inflammation in
adipose tissue with consumption of an obesogenic diet, thus driving the development of …

Abstract Background Protein arginine methyltransferases (PRMTs) regulate protein
biological activity by modulating arginine methylation in cancer and are increasingly …

Ethnopharmacological relevance Boesenbergia rotunda (L.) Mansf. Kulturpfl., previously
known as Boesenbergia pandurata (Family: Zingiberaceae) is a ginger species, locally …

Gouty arthritis is characterized by an intense inflammatory response to monosodium urate
crystals (MSU), which induces severe pain and reduction in the life quality of patients. Trans …

Finding an effective therapeutic to prevent or cure AD has been difficult due to the
complexity of the brain and limited experimental models. This study utilized unmodified and …

Inflammation is a complex biological response to stimuli. Activated macrophages induced
excessively release of pro-inflammatory cytokines and mediators such as endogenous …

Chalcone derivatives, as a hot research field, exhibit a variety of physiological bioactivities
and target multiple biological receptors. Based on the skeleton of (E)-1, 3-diphenyl-2 …

In this study, three different chalcone compounds were synthesized by Aldol condensation
reaction. 4-hydroxybenzaldehyde and ketone compounds (acetophenone, acetofuran and …