Biomarkers in cardiorenal syndrome and potential insights into novel therapeutics

EYM Chung, K Trinh, J Li, SH Hahn… - Frontiers in …, 2022 - frontiersin.org
Heart and kidney failure often co-exist and confer high morbidity and mortality. The complex
bi-directional nature of heart and kidney dysfunction is referred to as cardiorenal syndrome …

The diuretic effects of SGLT2 inhibitors: A comprehensive review of their specificities and their role in renal protection

P Delanaye, AJ Scheen - Diabetes & metabolism, 2021 - Elsevier
Sodium-glucose cotransporter type 2 inhibitors (SGLT2is) are new oral glucose-lowering
agents that provide cardiovascular and renal protection in both patients with and without …

Biomarkers of acute kidney injury after cardiac surgery: a narrative review

B Wu, J Chen, Y Yang - BioMed research international, 2019 - Wiley Online Library
Cardiac surgery‐associated acute kidney injury (CSA‐AKI) is a major and serious
complication in patients undergoing cardiac surgery and is independently associated with …

Pathogenesis and clinical presentation of acute heart failure

P Ponikowski, EA Jankowska - Revista Española de Cardiología (English …, 2015 - Elsevier
Acute heart failure constitutes a heterogeneous clinical syndrome, whose pathophysiology
is complex and not completely understood. Given the diversity of clinical presentations …

Acute renal injury events in diabetic patients treated with SGLT2 inhibitors: a comprehensive review with a special reference to RAAS blockers

AJ Scheen, P Delanaye - Diabetes & Metabolism, 2022 - Elsevier
Renin-angiotensin-aldosterone system (RAAS) blockers and sodium-glucose cotransporter
type 2 inhibitors (SGLT2is) are two pharmacological classes that proved a remarkable …

Urinary [TIMP‐2]×[IGFBP7] for risk prediction of acute kidney injury in decompensated heart failure

M Schanz, J Shi, C Wasser, MD Alscher… - Clinical …, 2017 - Wiley Online Library
Background In acute decompensated heart failure (ADHF) the risk of acute kidney injury
(AKI) is high. Early detection of patients at risk for AKI is important. We tested urinary [TIMP …

Sodium–glucose cotransporter 2 inhibitors: renal outcomes according to baseline albuminuria

P Delanaye, KM Wissing, AJ Scheen - Clinical Kidney Journal, 2021 - academic.oup.com
Sodium–glucose co-transporter 2 inhibitors (SGLT2is) reduce albuminuria and hard renal
outcomes (decline of renal function, renal replacement therapy and renal death) in patients …

Patogenia y presentación clínica de la insuficiencia cardiaca aguda

P Ponikowski, EA Jankowska - Revista Española de Cardiología, 2015 - Elsevier
La insuficiencia cardiaca aguda es un síndrome clínico heterogéneo, cuya fisiopatología es
compleja y no se conoce por completo. Dada la diversidad de formas de presentación …

Renal function and acute heart failure outcome

L Llauger, J Jacob, O Miro - Medicina Clínica (English Edition), 2018 - Elsevier
The interaction between acute heart failure (AHF) and renal dysfunction is complex. Several
studies have evaluated the prognostic value of this syndrome. The aim of this systematic …

Understanding the protective effects of SGLT2 inhibitors in type 2 diabetes patients with chronic kidney disease

AJ Scheen, P Delanaye - Expert Review of Endocrinology & …, 2022 - Taylor & Francis
Introduction Sodium-glucose co-transporter type 2 inhibitors (SGLT2is) were developed as
glucose-lowering agents for the management of type 2 diabetes (T2D). Unexpectedly, they …