Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

Fat and carbohydrate are important fuels for aerobic exercise and there can be reciprocal
shifts in the proportions of carbohydrate and fat that are oxidized. The interaction between …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …

Skeletal muscle plays important roles in whole-body glucose and fatty acid metabolism.
However, muscle also secretes cytokines and growth factors (collectively termed myokines) …

The peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α) is a
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …

The uptake and metabolism of long chain fatty acids (LCFA) are critical to many
physiological and cellular processes. Aberrant accumulation or depletion of LCFA underlie …

Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …

Lipid uptake and metabolism are central to the function of organs such as heart, skeletal
muscle, and adipose tissue. Although most heart energy derives from fatty acids (FAs) …