Cell adhesion molecules (CAMs) play a significant role in the metastatic potential of
colorectal cancer and thus mediate the prognosis of this common malignancy. The …

The liver is a highly metastasis-permissive organ, tumor seeding of which usually portends
mortality. Its unique and diverse architectural and cellular composition enable the liver to …

Liver metastasis is the major cause of death associated to colorectal cancer. Cadherin-17
(CDH17) is a non-classical, seven domain, cadherin lacking the conserved cytoplasmic …

Ezrin is a membrane-cytoskeleton anchor, which, in experimental models, regulates tumor
cell invasion and metastatic ability. We carried out immunohistochemical analysis of ezrin in …

The effects of histone deacetylase (HDAC) inhibitors on epithelial-mesenchymal transition
(EMT) differ in various types of cancers. We investigated the EMT phenotype in four colon …

BACKGROUND Chloride channel accessory 1 (CLCA1) is a CLCA protein that plays a
functional role in regulating the differentiation and proliferation of colorectal cancer (CRC) …

Cervical cancer is the third most common cancer in females worldwide. The treatment
options for advanced cervical cancer are limited, leading to high mortality. Ezrin is a …

Background Collective cell migration, whereby the cell–cell contacts such as E‐cadherin are
maintained during migration, has only recently emerged, and its detailed mechanisms are …

APC/β-catenin pathway perturbation is a common early event in colorectal carcinogenesis
and is affected by calcium and vitamin D in basic science studies. To assess the effects of …

The humanized monoclonal antibody-drug conjugate trastuzumab emtansine (T-DM1,
Kadcyla) has been approved by the US FDA to treat human epidermal growth factor receptor …