Fluorescence spectroscopy is frequently used to analyze the concentration of fluorescent
materials in solution. However, in conventional fluorescence spectroscopy, the response …

Amyloids are protein aggregates with the cross-β structure. The interest in amyloids is
explained, on the one hand, by their role in the development of socially significant human …

Fluorescent probes thioflavin T (ThT) and 1-anilino-8-naphthalene sulfonate (ANS) are
widely used to study amyloid fibrils that accumulate in the body of patients with serious …

Thioflavin-T (ThT) is the most commonly used fluorescent dye for following amyloid
formation semi-quantitatively in vitro, specifically probing the fibrillar cross-β-sheet content …

Single-molecule assays have, by definition, the ultimate sensitivity and represent the next
frontier in biological analysis and diagnostics. However, many of these powerful …

Oligomeric amyloid structures are crucial therapeutic targets in Alzheimer's and other
amyloid diseases. However, these oligomers are too small to be resolved by standard light …

The formation of amyloid fibrils is linked to multiple neurodegenerative disorders, including
Alzheimer's and Parkinson's disease. Despite years of research and countless studies on …

Amyloidogenic protein aggregation into highly structured fibrils is linked to more than 30
amyloidoses, including several neurodegenerative disorders. Despite significant progress in …

In this work, α-synuclein amyloid fibrils—the formation of which is a biomarker of Parkinson's
disease—were investigated using the fluorescent probe thioflavin T (ThT). The experimental …

Millions of people around the world suffer from amyloid-related disorders, including
Alzheimer's and Parkinson's diseases. Despite significant and sustained efforts, there are …