The role of Gβγ subunits in cellular signaling has become well established in the past 20
years. Not only do they regulate effectors once thought to be the sole targets of Gα subunits …

Many receptors for neurotransmitters and hormones rely upon members of the Gqα family of
heterotrimeric G proteins to exert their actions on target cells. Gα subunits of the Gq class of …

The control over the extent and timing of G protein signaling is provided by the regulator of G
protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian …

Background Carotenoids contribute significantly to animal body coloration, including the
spectacular color pattern diversity among fishes. Fish, as other animals, derive carotenoids …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

G protein-coupled receptor signaling pathways mediate the transmission of signals from the
extracellular environment to the generation of cellular responses, a process that is critically …

Leveraging the conserved cancer genomes across mammals has the potential to transform
driver gene discovery in orphan cancers. Here, we combine cross-species genomics with …

Rationale: Parasympathetic regulation of heart rate is mediated by acetylcholine binding to
G protein–coupled muscarinic M2 receptors, which activate heterotrimeric Gi/o proteins to …

Body color is an important economic and ecological trait in aquatic animals, which influence
their economic values and determine the animal ability to survive in the marine environment …

The RGS7 (R7) family of RGS proteins bound to the divergent Gβ subunit Gβ5 is a crucial
regulator of G protein–coupled receptor (GPCR) signaling in the visual and nervous …