Autophagy: a multifaceted player in the fate of sperm

M Wang, L Zeng, P Su, L Ma, M Zhang… - Human Reproduction …, 2022 - academic.oup.com
BACKGROUND Autophagy is an intracellular catabolic process of degrading and recycling
proteins and organelles to modulate various physiological and pathological events …

Functional diversity of protein phosphatase-1, a cellular economizer and reset button

H Ceulemans, M Bollen - Physiological reviews, 2004 - journals.physiology.org
Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …

Proteomic analysis of a eukaryotic cilium

GJ Pazour, N Agrin, J Leszyk, GB Witman - The Journal of cell biology, 2005 - rupress.org
Cilia and flagella are widespread cell organelles that have been highly conserved
throughout evolution and play important roles in motility, sensory perception, and the life …

Genetic dissection of mammalian fertility pathways

MM Matzuk, DJ Lamb - Nature Medicine, 2002 - nature.com
The world's population is increasing at an alarming rate and is projected to reach nine billion
by 2050. Despite this, 15% of couples world-wide remain childless because of infertility. Few …

Protein serine/threonine phosphatases: keys to unlocking regulators and substrates

DL Brautigan, S Shenolikar - Annual review of biochemistry, 2018 - annualreviews.org
Protein serine/threonine phosphatases (PPPs) are ancient enzymes, with distinct types
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …

The spermatozoon

EM Eddy, D O'brien - Knobil and Neill's physiology of …, 2006 - books.google.com
This chapter examines the novel structural features of the spermatozoon, their composition
and assembly, and the mechanisms regulating their function. The spermatozoon is a highly …

Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases

MA Battistone, VG Da Ros, AM Salicioni… - MHR: Basic science …, 2013 - academic.oup.com
In all mammalian species studied so far, sperm capacitation correlates with an increase in
protein tyrosine (Tyr) phosphorylation mediated by a bicarbonate-dependent cAMP/protein …

Sperm chromatin proteomics identifies evolutionarily conserved fertility factors

DS Chu, H Liu, P Nix, TF Wu, EJ Ralston, JR Yates III… - Nature, 2006 - nature.com
Male infertility is a long-standing enigma of significant medical concern. The integrity of
sperm chromatin is a clinical indicator of male fertility and in vitro fertilization potential …

Advances in non-hormonal male contraception targeting sperm motility

NAP Mariani, JV Silva, M Fardilha… - Human Reproduction …, 2023 - academic.oup.com
BACKGROUND The high rates of unintended pregnancy and the ever-growing world
population impose health, economic, social, and environmental threats to countries …

Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility

NA Spiridonov, L Wong, PM Zerfas… - … and cellular biology, 2005 - Am Soc Microbiol
Here we describe and characterize a small serine/threonine kinase (SSTK) which consists
solely of the N-and C-lobes of a protein kinase catalytic domain. SSTK protein is highly …