Mitochondria in the cell are the center for energy production, essential biomolecule
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …

Background Mitophagy refers to the selective self‐elimination of mitochondria under
damaged or certain developmental conditions. As an important regulatory mechanism to …

Protein misfolding is linked to a wide array of human disorders, including Alzheimer's
disease, Parkinson's disease and type II diabetes,. Protective cellular protein quality control …

Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …

Abstract The NLRP3 (NOD−, LRR− and pyrin domain-containing protein 3) inflammasome
plays a pivotal role in defending the host against infection as well as sterile inflammation …

Staphylococcus aureus invades cells and persists intracellularly, causing persistent
inflammation that is notoriously difficult to treat. Here we investigated host–pathogen …

Mitochondria are dynamic organelles engaged in quality control and aging processes. They
constantly undergo fusion, fission, transport, and anchoring events, which empower …

The endoplasmic reticulum (ER) is an essential compartment of the biosynthesis, folding,
assembly, and trafficking of secretory and transmembrane proteins, and consequently …

Ferroptosis, which is driven by iron-dependent lipid peroxidation, plays an essential role in
liver ischemia-reperfusion injury (IRI) during liver transplantation (LT). Gp78, an E3 ligase …

Alveolar macrophages (AMs) are specialized tissue-resident macrophages that orchestrate
the immune response in allergic inflammation and asthma. However, what signals direct …