As part of their life cycle, neutralophilic bacteria are often exposed to varying environmental
stresses, among which fluctuations in pH are the most frequent. In particular, acid …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Modifying proteins with new methods to improve their functional properties is essential to
extend their application in food related field. In this study, the effect of pH-shifting treatment …

Parkinson's disease involves the aggregation of α-synuclein to form fibrils, which are the
major constituent of intracellular protein inclusions (Lewy bodies and Lewy neurites) in …

Circular dichroism (CD) is an excellent spectroscopic technique for following the unfolding
and folding of proteins as a function of temperature. One of its principal applications is to …

Many globular proteins are good emulsifiers or stabilizers for oil-in-water emulsions. It is
generally recognized in the field that globular proteins tend to undergo a structural unfolding …

The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

Structural unfolding of soy protein isolate (SPI) as induced by holding (0, 0.5, 1, 2, and 4 h)
in acidic (pH 1.5− 3.5) and alkaline (pH 10.0− 12.0) pH solutions, followed by refolding (1 h) …

Amyloid fibrils are supramolecular homopolymers of proteins that play important roles in
biological functions and disease. These objects have received an exponential increase in …

Publisher Summary This chapter describes the present state of the studies of the molten
globule state and its role in protein folding and physiological processes. Recent data on the …