Statins and prostate cancer—hype or hope? The epidemiological perspective

EL Craig, KH Stopsack, E Evergren, LZ Penn… - Prostate cancer and …, 2022 - nature.com
Background Men using cholesterol-lowering statin medications have been found to have
lower risks of both advanced and fatal prostate cancer in multiple registry-based studies and …

Association of Statin Use with the Risk of Incident Prostate Cancer: A Meta‐Analysis and Systematic Review

MY Xu, Y An, CQ Liu, JZ Xu, XY Zhong… - Journal of …, 2022 - Wiley Online Library
Background. With the growth and aging of population, the incidence of prostate cancer will
increase year by year, which is bound to bring greater economic burden to the society …

A meta‐analysis of statin use and risk of hepatocellular carcinoma

Y Wang, W Wang, M Wang, J Shi… - Canadian Journal of …, 2022 - Wiley Online Library
Background. The use of statins is a potential protective factor against the development of
hepatocellular carcinoma. Therefore, we conducted a meta‐analysis to evaluate the …

Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. A population-based cohort study

AI Peltomaa, P Raittinen, K Talala, K Taari… - Prostate cancer and …, 2021 - nature.com
Purpose Statins' cholesterol-lowering efficacy is well-known. Recent epidemiological studies
have found that inhibition of cholesterol synthesis may have beneficial effects on prostate …

Population-wide impacts of aspirin, statins, and metformin use on prostate cancer incidence and mortality

HY Koo, SM Jeong, MH Cho, S Chun, DW Shin… - Scientific Reports, 2021 - nature.com
We evaluated the association between aspirin, statins, and metformin use and prostate
cancer (PC) incidence and mortality using a large population-based dataset. 388,760 men …

Association of statin use with risk of Gleason score‐specific prostate cancer: A hospital‐based cohort study

K Wang, TA Gerke, X Chen, M Prosperi - Cancer medicine, 2019 - Wiley Online Library
Background Conflicting evidence suggests that statins act chemopreventively against
prostate cancer (PCa). Whether the association of statin use with PCa risk is Gleason score …

Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in …

S Mallappa, PK Neeli, S Karnewar… - Molecular …, 2019 - Wiley Online Library
Multidrug resistance mediated by ATP‐binding cassette (ABC) transporters remains a major
impediment to cancer chemotherapy. In the present study, we documented that doxorubicin …

Can statin treatment reduce the risk of hepatocellular carcinoma? A systematic review and meta-analysis

Y Chang, Q Liu, Z Zhou, Y Ding… - … in cancer research …, 2020 - journals.sagepub.com
Background: Whether statins can reduce the incidence of cancers has been an interesting
topic in recent years. This meta-analysis aimed to determine the relationship between statin …

Statin Use and Prostate Cancer Incidence in Manitoba, Canada: A Population-Based Nested Case–Control Study

CH Righolt, R Bisewski, SM Mahmud - Cancer Epidemiology, Biomarkers & …, 2019 - AACR
Background: A link between statin use and prostate cancer risk has been proposed.
Epidemiologic evidence is, however, inconclusive, and data for specific statin types as well …

The Association of Prediagnostic Statin Use with Aggressive Prostate Cancer from the Multiethnic Cohort Study

F Chen, P Wan, L R. Wilkens, L Le Marchand… - … Biomarkers & Prevention, 2022 - AACR
Background: There is a growing body of evidence supporting the protective effect of statins
on the risk of prostate cancer, in particular aggressive disease. Past research has mostly …