The multifaceted role of reactive oxygen species in tumorigenesis
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …
various normal cellular functions including cellular growth, differentiation, senescence …
The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic …
Pancreatic ductal adenocarcinoma (PDAC) is one of the lethal malignancies with the lowest
median and overall survival rate among all human malignancies. The major problems with …
median and overall survival rate among all human malignancies. The major problems with …
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
Triple-negative breast cancer (TNBC) lacks targeted therapies and has a worse prognosis
than other breast cancer subtypes, underscoring an urgent need for new therapeutic targets …
than other breast cancer subtypes, underscoring an urgent need for new therapeutic targets …
The structure, activation and signaling of IRE1 and its role in determining cell fate
N Siwecka, W Rozpędek-Kamińska, A Wawrzynkiewicz… - Biomedicines, 2021 - mdpi.com
Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three
branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated …
branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated …
Role of endoplasmic reticulum stress sensor IRE1α in cellular physiology, calcium, ROS signaling, and metaflammation
Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most
prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer …
prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer …
[HTML][HTML] The emerging role of XBP1 in cancer
S Chen, J Chen, X Hua, Y Sun, R Cui, J Sha… - Biomedicine & …, 2020 - Elsevier
X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription
factor whose dynamic form is controlled by an alternative splicing response upon …
factor whose dynamic form is controlled by an alternative splicing response upon …
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer
G Genovese, A Carugo, J Tepper, FS Robinson, L Li… - Nature, 2017 - nature.com
Malignant neoplasms evolve in response to changes in oncogenic signalling. Cancer cell
plasticity in response to evolutionary pressures is fundamental to tumour progression and …
plasticity in response to evolutionary pressures is fundamental to tumour progression and …
[HTML][HTML] IRE1α implications in endoplasmic reticulum stress-mediated development and pathogenesis of autoimmune diseases
RP Junjappa, P Patil, KR Bhattarai, HR Kim… - Frontiers in …, 2018 - frontiersin.org
Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most
prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein …
prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein …
A comprehensive review of the multifaceted role of the microbiota in human pancreatic carcinoma
G Pandya, A Kirtonia, A Singh, A Goel… - Seminars in cancer …, 2022 - Elsevier
Pancreatic carcinoma is associated with one of the worst clinical outcomes throughout the
globe because of its aggressive, metastatic, and drug-resistant nature. During the past …
globe because of its aggressive, metastatic, and drug-resistant nature. During the past …
The unfolded protein response in breast cancer
In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast
cancer, and that 41,400 will die from it. Since breast cancers often become resistant to …
cancer, and that 41,400 will die from it. Since breast cancers often become resistant to …