The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …

Membrane and secretory proteins are essential for almost every aspect of cellular function.
These proteins are incorporated into ER-derived carriers and transported to the Golgi before …

Complex machinery is required to drive secretory cargo export from the endoplasmic
reticulum (ER), which is an essential process in eukaryotic cells. In vertebrates, the MIA3 …

SEC23, the core component of the coat protein complex II (COPII), functions to transport
newly synthesized proteins and lipids from the endoplasmic reticulum (ER) to the Golgi …

To date, very few mass spectrometry (MS)–based proteomics studies are available on the
anterior and posterior lobes of the pituitary. In the past, MS-based investigations have …

Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring
and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic …

Coat protein complex II (COPII) factors mediate cargo export from the endoplasmic reticulum
(ER), but bulky collagens and lipoproteins are too large for traditional COPII vesicles …

Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal
axons. Abnormal myelin sheath is associated with many neurological diseases. Meningioma …

Mutations of TRAPPC12 are associated with progressive childhood encephalopathy
including abnormal white matter. However, the underlying pathogenesis is still unclear …

The early secretory pathway, provisionally comprising of vesicular traffic between the
endoplasmic reticulum (ER) and the Golgi apparatus, occurs constitutively in mammalian …