Background Daily rhythms are observed in humans and almost all other organisms. Most of
these observed rhythms reflect both underlying endogenous circadian rhythms and evoked …

In humans, an adaptable internal biological system generates circadian rhythms that
maintain synchronicity of behavior and physiology with the changing demands of the 24-h …

Studies in shift workers and model organisms link circadian disruption to breast cancer.
However, molecular circadian rhythms in noncancerous and cancerous human breast …

Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and
adapt to daily changes in the environment. Synchronized to the light–dark cycle with a …

Skin cancers are growing in incidence worldwide and are primarily caused by exposures to
ultraviolet (UV) wavelengths of sunlight. UV radiation induces the formation of photoproducts …

Shift work, involving night work, leads to impaired sleep, cognition, health and wellbeing,
and an increased risk of occupational incidents. Current countermeasures include circadian …

The circadian system temporally regulates physiology to maintain homeostasis. Co-opting
and disrupting circadian signals appear to be distinct attributes that are functionally …

Clock (circadian) genes are heterogeneously expressed in hair follicles (HFs). The genes
can be modulated by both the central circadian system and some extrinsic factors, such as …

The skin is the largest human organ with a circadian clock that regulates its function.
Although circadian rhythms in specific functions are known, rhythms in the proximal clock …

Disruption of the circadian clock is linked to cancer development and progression.
Establishing this connection has proven beneficial for understanding cancer pathogenesis …