Keeping an eye on circadian time in clinical research and medicine
EB Klerman, A Brager, MA Carskadon… - Clinical and …, 2022 - Wiley Online Library
Background Daily rhythms are observed in humans and almost all other organisms. Most of
these observed rhythms reflect both underlying endogenous circadian rhythms and evoked …
these observed rhythms reflect both underlying endogenous circadian rhythms and evoked …
Development of the circadian system in early life: maternal and environmental factors
In humans, an adaptable internal biological system generates circadian rhythms that
maintain synchronicity of behavior and physiology with the changing demands of the 24-h …
maintain synchronicity of behavior and physiology with the changing demands of the 24-h …
Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer
SY Li, JA Hammarlund, G Wu… - Proceedings of the …, 2024 - National Acad Sciences
Studies in shift workers and model organisms link circadian disruption to breast cancer.
However, molecular circadian rhythms in noncancerous and cancerous human breast …
However, molecular circadian rhythms in noncancerous and cancerous human breast …
The circadian clock and diseases of the skin
J Duan, EN Greenberg, SS Karri, B Andersen - FEBS letters, 2021 - Wiley Online Library
Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and
adapt to daily changes in the environment. Synchronized to the light–dark cycle with a …
adapt to daily changes in the environment. Synchronized to the light–dark cycle with a …
The impact of the circadian clock on skin physiology and cancer development
Skin cancers are growing in incidence worldwide and are primarily caused by exposures to
ultraviolet (UV) wavelengths of sunlight. UV radiation induces the formation of photoproducts …
ultraviolet (UV) wavelengths of sunlight. UV radiation induces the formation of photoproducts …
Move the night way: how can physical activity facilitate adaptation to shift work?
Shift work, involving night work, leads to impaired sleep, cognition, health and wellbeing,
and an increased risk of occupational incidents. Current countermeasures include circadian …
and an increased risk of occupational incidents. Current countermeasures include circadian …
The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics
The circadian system temporally regulates physiology to maintain homeostasis. Co-opting
and disrupting circadian signals appear to be distinct attributes that are functionally …
and disrupting circadian signals appear to be distinct attributes that are functionally …
Hair follicles as a critical model for monitoring the circadian clock
LP Liu, MH Li, YW Zheng - International Journal of Molecular Sciences, 2023 - mdpi.com
Clock (circadian) genes are heterogeneously expressed in hair follicles (HFs). The genes
can be modulated by both the central circadian system and some extrinsic factors, such as …
can be modulated by both the central circadian system and some extrinsic factors, such as …
Inter-layer and inter-subject variability of diurnal gene expression in human skin
M Del Olmo, F Spörl, S Korge, K Jürchott… - NAR Genomics and …, 2022 - academic.oup.com
The skin is the largest human organ with a circadian clock that regulates its function.
Although circadian rhythms in specific functions are known, rhythms in the proximal clock …
Although circadian rhythms in specific functions are known, rhythms in the proximal clock …
The circadian clock is disrupted in pancreatic cancer
PB Schwartz, M Nukaya, ME Berres… - PLoS …, 2023 - journals.plos.org
Disruption of the circadian clock is linked to cancer development and progression.
Establishing this connection has proven beneficial for understanding cancer pathogenesis …
Establishing this connection has proven beneficial for understanding cancer pathogenesis …