Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus,
which forms an amphipathic alpha-helix upon membrane interaction. Here we show that …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

α-Synuclein (αsyn) is an abundant brain neuronal protein that can misfold and polymerize to
form toxic fibrils coalescing into pathologic inclusions in neurodegenerative diseases …

As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large
conformational space. Certain conformations lead to aggregation prone and non …

Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world. Its causes are poorly understood and there is no proven therapeutic strategy for …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …